• Publications
  • Influence
Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia
Evaluating the distribution of hematopoietic cell subsets along an in vivo Hoechst 33342 (Ho) dye perfusion gradient indicates that HSCs and the supporting cells of the stem cell niche are predominantly located at the lowest end of an oxygen gradient in the bone marrow with the implication that regionally defined hypoxia plays a fundamental role in regulating stem cell function. Expand
Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone
It is established that the HCELL glycoform of CD44 confers tropism to bone and unveil a readily translatable roadmap for programming cellular trafficking by chemical engineering of glycans on a distinct membrane glycoprotein. Expand
Cd44 Is a Major E-Selectin Ligand on Human Hematopoietic Progenitor Cells
A shear-based adherence assay is used to analyze and define the E-selectin ligand activity of membrane proteins from human HPCs and offers new insights into the structural biology and physiology of CD44, and into the molecular basis of E- selectin–dependent adhesive interactions that direct homing of human H PC to BM. Expand
Intentional induction of mixed chimerism and achievement of antitumor responses after nonmyeloablative conditioning therapy and HLA-matched donor bone marrow transplantation for refractory
Mixed lymphohematopoietic chimerism was reproducibly induced after a novel nonmyeloablative preparative regimen incorporating chemotherapy, peritransplant antithymocyte globulin, and thymic irradiation, allowing for early administration of DLI in 10 of 21 patients. Expand
The lymphocyte homing receptors: gatekeepers of the multistep paradigm
  • R. Sackstein
  • Biology, Medicine
  • Current opinion in hematology
  • 1 November 2005
The cross-talk among the homing receptors and integrins opens a new ‘avenue’ to lymphocyte migration, suggesting that homing receptor may be sufficient alone, in some cases, to perform the function the name implies. Expand
CD44 on LS174T colon carcinoma cells possesses E-selectin ligand activity.
The finding that tumor-associated CD44 splice variant(s) express E-selectin ligand activity provides novel perspectives on the biology of CD44 in cancer metastasis. Expand
SDF-1/CXCR4 and VLA-4 interaction regulates homing in Waldenstrom macroglobulinemia.
It is demonstrated that the CXCR4/SDF-1 axis interacts with VLA-4 in regulating migration and adhesion of WM cells in the bone marrow microenvironment. Expand
Impact of prophylactic donor leukocyte infusions on mixed chimerism, graft-versus-host disease, and antitumor response in patients with advanced hematologic malignancies treated with nonmyeloablative
PDLI has the potential to convert MC to FDC; sustained remissions can be achieved in patients with chemorefractory hematologic malignancies who receive a pDLI, albeit with a significant risk of acute GVHD; and the degree of donor T cell chimerism at the time of p DLI is predictive of the fate of MC. Expand
Desialylation accelerates platelet clearance after refrigeration and initiates GPIbα metalloproteinase-mediated cleavage in mice.
Desialylation of platelet VWFR triggers platelet clearance and primes GPIbα and GPV for MP-dependent cleavage, which causes the rapid clearance of platelets from circulation. Expand
HCELL Is the Major E- and L-selectin Ligand Expressed on LS174T Colon Carcinoma Cells*
Data indicate that expression of HCELL confers robust and predominant tumor cell binding to E- and L-selectin, highlighting a central role for H CELL in promoting shear-resistant adhesive interactions essential for hematogenous cancer dissemination. Expand