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The human phase response curve (PRC) to melatonin is about 12 hours out of phase with the PRC to light.
The human phase response curve (PRC) to melatonin appears to be about 12h out of phase with the PRC to light, which suggests that a function for endogenous melatonin is to augment entrainment of the circadian pacemaker by the light-dark cycle.
Antidepressant and circadian phase-shifting effects of light.
The antidepressant response to morning light was accompanied by an advance in the onset of nighttime melatonin production, suggesting that timing may be critical for the antidepressant effects of bright light.
Morning vs evening light treatment of patients with winter depression.
Morning light phase-advanced the dim-light melatonin onset and was more antidepressant than evening light, which phase-delayed it, which should help establish the importance of circadian time of light exposure in the treatment of winter depression.
Melatonin shifts human circadian rhythms according to a phase-response curve.
The human melatonin PRC provides critical information for using melatonin to treat circadian phase sleep and mood disorders, as well as maladaptation to shift work and transmeridional air travel.
Circadian rhythm sleep disorders: part II, advanced sleep phase disorder, delayed sleep phase disorder, free-running disorder, and irregular sleep-wake rhythm. An American Academy of Sleep Medicine…
Circadian rhythm science has also pointed the way to rational interventions for CRSDs and these treatments have been introduced into the practice of sleep medicine with varying degrees of success.
Circadian rhythm sleep disorders: part I, basic principles, shift work and jet lag disorders. An American Academy of Sleep Medicine review.
Circadian rhythm science has also pointed the way to rational interventions for the SWD and JLD, and these treatments have been introduced into the practice of sleep medicine with varying degrees of success.
The Endogenous Melatonin Profile as a Marker for Circadian Phase Position
The dim-light melatonin offset (DLMOff), even when operationally defined at thresholds less than 10 pg/ml, appears to be confounded by amplitude in this study; in such cases, it may be preferable to use the melatonin synthesis offset (SynOff) because it is not confounding by amplitude and because, theoretically, it is temporally closer to the endogenous mechanism signaling the offset of production.
Circadian rhythm abnormalities in totally blind people: incidence and clinical significance.
- R. Sack, A. Lewy, M. L. Blood, L. Keith, H. Nakagawa
- Psychology, BiologyThe Journal of clinical endocrinology and…
- 1 July 1992
The high incidence of abnormal circadian rhythms in blind people underscores the importance of the light-dark cycle as an important environmental synchronizer for the human circadian system.
The dim light melatonin onset as a marker for circadian phase position.
By measuring the onset of melatonin production, a clearly demarcated event, the authors can reliably assess circadian phase position, provided blood is sampled under dim light (the dim light melatonin onset, or DLMO), which has been useful in assessing the phase-shifting properties of bright light and in phase typing patients with chronobiologic disorders, such as winter depression.
Entrainment of free-running circadian rhythms by melatonin in blind people.
- R. Sack, R. Brandes, A. R. Kendall, A. Lewy
- Medicine, PsychologyThe New England journal of medicine
- 12 October 2000
Administration of melatonin can entrain circadian rhythms in most blind people who have free-running rhythms, and in six of the seven subjects the rhythm was entrained to a 24.0-hour cycle during melatonin treatment.