• Publications
  • Influence
NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders
The number and subunit composition of synaptic N-methyl-D-aspartate receptors (NMDARs) are not static, but change in a cell- and synapse-specific manner during development and in response to neuronalExpand
  • 987
  • 63
  • PDF
Dysregulation of mTOR Signaling in Fragile X Syndrome
Fragile X syndrome, the most common form of inherited mental retardation and leading genetic cause of autism, is caused by transcriptional silencing of the Fmr1 gene. The fragile X mental retardationExpand
  • 455
  • 49
  • PDF
Ca2+-permeable AMPA receptors in synaptic plasticity and neuronal death
AMPA receptors mediate fast synaptic transmission at excitatory synapses in the CNS and are crucial during neuronal development, synaptic plasticity and structural remodeling. AMPA receptors lackingExpand
  • 432
  • 33
  • PDF
Ischemic Insults Derepress the Gene Silencer REST in Neurons Destined to Die
A subset of genes implicated in genetic and acquired neurological disorders encode proteins essential to neural patterning and neurogenesis. The gene silencing transcription factor neuronal repressorExpand
  • 291
  • 24
  • PDF
Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders.
Epigenetic chromatin remodeling and modifications of DNA represent central mechanisms for regulation of gene expression during brain development and in memory formation. Emerging evidence implicatesExpand
  • 432
  • 20
Protein kinase A regulates calcium permeability of NMDA receptors
Calcium (Ca2+) influx through NMDA receptors (NMDARs) is essential for synaptogenesis, experience-dependent synaptic remodeling and plasticity. The NMDAR-mediated rise in postsynaptic Ca2+ activatesExpand
  • 263
  • 18
  • PDF
The GluR2 (GluR-B) hypothesis: Ca2+-permeable AMPA receptors in neurological disorders
The abnormal influx of Ca2+ through glutamate receptor channels is thought to contribute to the loss of neurons associated with a number of brain disorders. Until recently, the NMDA receptor was theExpand
  • 517
  • 17
Protein kinase C modulates NMDA receptor trafficking and gating
Regulation of neuronal N-methyl-d-aspartate receptors (NMDARs) by protein kinases is critical in synaptic transmission. However, the molecular mechanisms underlying protein kinase C (PKC)Expand
  • 383
  • 17
Alternatively spliced isoforms of the NMDARI receptor subunit
Molecularly diverse forms of the NMDA-receptor subunit NRI are formed by alternative RNA splicing. Differential splicing of three exons generates as many as eight NRI splice variants, seven of whichExpand
  • 438
  • 16
HIV-tat induces formation of an LRP–PSD-95– NMDAR–nNOS complex that promotes apoptosis in neurons and astrocytes
HIV infection of the central nervous system can result in neurologic dysfunction with devastating consequences in AIDS patients. NeuroAIDS is characterized by neuronal injury and loss, yet there isExpand
  • 166
  • 16