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CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life
TLDR
Mice deficient in CuZn superoxide dismutase showed no overt abnormalities during development and early adulthood, but had a reduced lifespan and increased incidence of neoplastic changes in the liver, which likely contributes to hepatocarcinogenesis later in life. Expand
Iron regulatory proteins and the molecular control of mammalian iron metabolism.
TLDR
Evidence indicates that there is diversity in the function of the IRP system with respect to the response of specific IRPs to the same effector, as well as the selectivity with which IRPs modulate the use of specific messenger RNA. Expand
Mammalian iron metabolism and its control by iron regulatory proteins.
TLDR
A mechanistic understanding of IRP regulation will likely yield important insights into the basis of disorders of iron metabolism and is part of a Special Issue entitled: Cell Biology of Metals. Expand
Molecular control of vertebrate iron homeostasis by iron regulatory proteins.
TLDR
Recent evidence provides insight into how IRPs selectively control the translation or stability of target mRNAs, how IRP RNA binding activity is controlled by iron-dependent and iron-independent effectors, and the pathological consequences of dysregulation of the IRP system. Expand
The mitochondrial ATP-binding cassette transporter Abcb7 is essential in mice and participates in cytosolic iron-sulfur cluster biogenesis.
TLDR
It is found that Abcb7 was essential in extra-embryonic tissues early in gestation and that the mutant allele exhibits an X-linked parent-of-origin lethality effect, which substantiate a central role for mitochondria in the biogenesis of cytosolic Fe-S proteins. Expand
Evidence That Inhibition of Hemojuvelin Shedding in Response to Iron Is Mediated through Neogenin*
TLDR
The present study shows that knock-down of endogenous neogenin, a HJV receptor, in C2C12 cells suppresses HJV shedding and that overexpression of neogen in HEK293 cells markedly enhances this process, suggesting that membrane HJVsheding is mediated by neogenIn, the finding that neither BMP4 nor its antagonist, noggin, was able to alter HJV shed support the lack of involvement of BMP signaling pathway in this process. Expand
Regulation of ferritin and heme oxygenase synthesis in rat fibroblasts by different forms of iron.
TLDR
Results demonstrate that release of iron by HO plays an essential role in the induction of ferritin synthesis by heme and chelatable iron can regulate ferritIn synthesis independently of heme formation. Expand
Iron regulatory proteins, iron responsive elements and iron homeostasis.
TLDR
The targets of IRP action now appear to extend beyond proteins that function in the storage or cellular uptake of iron to include those involved in other aspects of iron metabolism as well as in the tricarboxylic acid cycle. Expand
The IRP1-HIF-2α axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption.
TLDR
These results uncover separable physiological roles of each IRP and identify IRP1 as a therapeutic target for manipulating HIF-2α action in hematologic, oncologic, and other disorders. Expand
Dietary iron intake modulates the activity of iron regulatory proteins and the abundance of ferritin and mitochondrial aconitase in rat liver.
TLDR
It is indicated that liver IRP activity is responsive to a range of dietary iron levels, there appears to be a differential effect of IRPs on ferritin and m-aconitase abundance, and activation of IRP may contribute to the alterations in energy metabolism in iron deficiency through an impairment of m-aconsitase synthesis. Expand
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