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Colorimetric assay of penicillin amidase activity using phenylacetyl-aminobenzoic acid as substrate.
Abstract All three isomers of phenylacetyl-aminobenzoic acid are stable in buffer solutions and are suitable as substrates for the simple and sensitive assay of penicillin amidase activity inExpand
Toxicity and hypolipaemic activity of benzoyl ester of polyoxethylene‐polyoxypropylene block copolymer (BEP) in rats
Dose response studies in rodents indicated that Pluronic L-81 given chronically has a low level of tolerance at higher doses resulting in poor food intake and diarrhoea, and attempts were made to develop a derivative that would be better tolerated while maintaining the basic activity of the original substance. Expand
Inhibition of lipid absorption by non‐ionic hydrophobic surfactant Pluronic L‐81, and its benzoyl esters
Inhibition of triolein absorption by Pluronic L‐81 may be partly related to its delaying action on Gastric emptying, as purified BEP preparations had practically no effect on gastric empties, their inhibiting activity involved intestinal mechanisms of lipid absorption. Expand
Molecular forms of cobalt-activated acylase in human tissues and serum of patients with viral hepatitis.
Two molecular forms of cobalt-activated acylase present in human tissues and one or three in sera of patients with viral hepatitis were noted. They have different substrate specificity. Only form 2Expand
Purification of cobalt-activated acylase by affinity chromatography.
alpha-Hydroxyisocaproyltyrosine (HyIc-Tyr-OH), a potent competitive inhibitor of the cobalt-activated acylase form 2, was synthesized and was used for about 100-fold purification of the acyl enzyme from human liver by affinity chromatography. Expand
Acylases in plasma of hamsters with experimental hepatitis.
After the administration of D-galactosamine to golden Syrian hamsters, a rapid but short-lived increase in acylase I and cobalt-activated (AA-Co) activity was noted in the blood plasma, but not inExpand
Alterations of secretory pattern of intestinal lipoproteins by the benzoyl ester derivative of poloxalene surfactant (BEP).
It was concluded that inhibition of lipid transport by BEP was not a result of apolipoprotein deficiency and Discontinuation of BEP administration resulted in a prompt recovery of the intestinal lipid transport system. Expand
Hydrophobic surfactant effects on aortic cholesterol accumulation and atherosclerosis in hypercholesterolemic rabbits.
It is concluded that Pol limits cholesterol accumulation in the aortic wall of hypercholesterolemic rabbits and can retard the development of atherosclerosis. Expand
Determination of amylase by measurement of enzymatic activity and by enzyme immunoassay and radioimmunoassay.
The highest enzyme content and activity were found in the pancreas among the studied organs, and close correlation was shown between the results obtained with the immunological and enzymatic methods. Expand
Enzyme immunoassay for alpha-amylase.
A sensitive sandwich enzyme immunoassay has been developed for quantitation of alpha-amylase in pig pancreas and the enzymatic activity determination and immunoASSay were compared in the material studied. Expand