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Physiological, neurochemical and morphological properties of a subgroup of GABAergic spinal lamina II neurones identified by expression of green fluorescent protein in mice
TLDR
EGFP expression defined a substantial but, with respect to the measured parameters, rather inhomogeneous subgroup of GABAergic neurones in spinal lamina II of the spinal dorsal horn, e.g. for nociception. Expand
Physical activity and memory functions: An interventional study
TLDR
It is shown that physical activity conveys the beneficial effects on memory function independently of its intensity, possibly mediated by local gray matter volume and neurotrophic factors. Expand
Lamina‐specific membrane and discharge properties of rat spinal dorsal horn neurones in vitro
TLDR
Differences in membrane and discharge properties probably contribute to lamina‐specific processing of sensory, including nociceptive, information. Expand
Synaptic Plasticity in Spinal Lamina I Projection Neurons That Mediate Hyperalgesia
TLDR
It is reported that in lamina I of the spinal dorsal horn, neurokinin 1 receptor–activated signal transduction pathways and activation of low-threshold (T-type) voltage-gated calcium channels synergistically facilitate activity- and calcium-dependent long-term potentiation at synapses from nociceptive nerve fibers. Expand
Pain sensitivity can be assessed by self-rating: Development and validation of the Pain Sensitivity Questionnaire
TLDR
A self‐rating instrument for the assessment of pain sensitivity, the Pain Sensitivity Questionnaire (PSQ) that is based on pain intensity ratings of daily life situations and takes 5–10 min to complete, shows that the PSQ may be a simple alternative to experimental pain intensity rating procedures in healthy subjects and makes thePSQ a highly promising tool for clinical and experimental pain research. Expand
Modification of classical neurochemical markers in identified primary afferent neurons with Aβ‐, Aδ‐, and C‐fibers after chronic constriction injury in mice
TLDR
This work identified neurons with Aβ‐, Aδ‐, and C‐fibers by their conduction velocity in dorsal root ganglia taken from mice after a chronic constriction injury (CCI) of the sciatic nerve and control mice, and stained them for IB4, SP, calcitonin gene‐related peptide (CGRP), NF200, and neuropeptide Y (NPY). Expand
Validation of the Pain Sensitivity Questionnaire in chronic pain patients
TLDR
It is demonstrated that the PSQ constitutes a valid self‐rating measure of pain perception outside the clinical pain site in chronic pain patients and might serve as an alternative to experimental assessment of pain Perception outside the clinic site in situations where experimental pain testing is not feasible. Expand
Physical activity and memory functions: Are neurotrophins and cerebral gray matter volume the missing link?
TLDR
It is found that physical activity, but not cardiovascular fitness, was associated with better memory encoding after controlling for age, sex, education, depression, alcohol consumption, and smoking, indicating that even low-level physical activity exerts beneficial effects on memory functions in older individuals. Expand
Long-term potentiation in spinal nociceptive pathways as a novel target for pain therapy
TLDR
An overview of targets for preventing LTP induction and modifying established LTP as identified in animal studies is given, which of the various symptoms of human experimental and clinical pain may be manifestations of spinal LTP and the pharmacology of these possible human LTP manifestations is reviewed. Expand
Distinctive membrane and discharge properties of rat spinal lamina I projection neurones in vitro
TLDR
Projection neurones, especially those of the burst firing type, were more easily excitable than unidentified neurones and received a larger proportion of monosynaptic input from primary afferent C‐fibres and many had a considerable extension in the mediolateral plane. Expand
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