Skip to search formSkip to main contentSkip to account menu

Screening of the Open Source Malaria Box Reveals an Early Lead Compound for the Treatment of Alveolar Echinococcosis

A newly developed screening cascade for the evaluation of the in vitro efficacy of new compounds that includes assessment of parasiticidal activity is described, and its effect on metacestode vesicles was morphologically evaluated by electron microscopy.
View PDF (opens in a new tab)

Treatment of echinococcosis: albendazole and mebendazole – what else?

The availability of comprehensive Echinococcus genome information and gene expression data, as well as significant progress on the molecular level, has now opened the door for a more targeted drug discovery approach, which allows exploitation of defined pathways and enzymes that are essential for the parasite.
View PDF (opens in a new tab)

Oral treatments of Echinococcus multilocularis-infected mice with the antimalarial drug mefloquine that potentially interacts with parasite ferritin and cystatin.

View on PubMed (opens in a new tab)

Drug repurposing applied: Activity of the anti-malarial mefloquine against Echinococcus multilocularis

View on PubMed (opens in a new tab)

Transcriptomic signature and metabolic programming of bovine classical and nonclassical monocytes indicate distinct functional specializations

Gene transcription indicates that pro-inflammatory and antibacterial processes are associated with cM, while ncM appear to be specialized in regulatory/anti-inflammatory functions and tissue repair, as well as antiviral responses and T-cell immunomodulation.
View via Publisher (opens in a new tab)

The importance of being parasiticidal… an update on drug development for the treatment of alveolar echinococcosis

View on PubMed (opens in a new tab)

Activity of mefloquine and mefloquine derivatives against Echinococcus multilocularis

View on PubMed (opens in a new tab)

Development of a movement-based in vitro screening assay for the identification of new anti-cestodal compounds

An in vitro-drug screening assay based on Echinococcus multilocularis protoscoleces, which represent precursors of the scolex of the adult tapeworm, can serve as a model for an adult cestode screen and demonstrates that this compound exhibits a mode of action clearly distinct from praziquantel.
View PDF (opens in a new tab)

Repurposing of an old drug: In vitro and in vivo efficacies of buparvaquone against Echinococcus multilocularis

View on PubMed (opens in a new tab)

To see or not to see: non-invasive imaging for improved readout of drug treatment trials in the murine model of secondary alveolar echinococcosis

An ultrasound (US)-based scoring system is developed that allows to follow-up parasite development in the living animal, and provides insights into parasite growth during the treatment phase, and the growth curve of the parasite load was described by a linear mixed model.
View on Cambridge Press (opens in a new tab)
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)