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Magnesium Deficiency: A Cause of Heterogenous Disease in Humans
- R. Rude
- BiologyJournal of bone and mineral research : the…
- 1 April 1998
Mg is actively transported into and out of cells and is influenced by various hormonal and pharmacological factors which perhaps regulate the intracellular Mg concentration and hence activity of Mg-sensitive enzymes.
Disorders of magnesium metabolism.
Sexual dimorphism in plasma leptin concentration.
Postmenopausal women had still higher leptin levels than men of similar age, and their levels were not different from those in younger women, which suggests that women may be resistant to its putative lipostatic actions and that it may have a reproductive function.
Skeletal and Hormonal Effects of Magnesium Deficiency
- R. Rude, F. Singer, H. Gruber
- Medicine, BiologyJournal of the American College of Nutrition
- 1 April 2009
The notion at dietary Mg intake at levels not uncommon in humans may perturb bone and mineral metabolism and be a risk factor for osteoporosis is supported.
Magnesium metabolism and deficiency.
- R. Rude
- Medicine, BiologyEndocrinology and metabolism clinics of North…
- 1 June 1993
Magnesium deficiency produces insulin resistance and increased thromboxane synthesis.
- J. Nadler, T. Buchanan, R. Natarajan, I. Antonipillai, R. Bergman, R. Rude
- Medicine, BiologyHypertension
- 1 June 1993
Dietary-induced magnesium deficiency increases thromboxane urinary concentration and enhances angiotensin-induced aldosterone synthesis, which are associated with a decrease in insulin action, suggesting that magnesium deficiency may be a common factor associated with insulin resistance and vascular disease.
Magnesium Deficiency in Critical Illness
Magnesium therapy is not supported in the treatment of acute myocardial infarction and is presently undergoing evaluation for thetreatment of severe asthma exacerbation, for the prevention of postcoronary bypass grafting dysrhythmias, and as a neuroprotective agent in acute cerebral ischemia.
Magnesium Deficiency: Effect on Bone and Mineral Metabolism in the Mouse
A profound effect of Mg depletion on bone is demonstrated by impaired bone growth, decreased osteoblast number, increased osteoclast number in young animals, and loss of trabecular bone with stimulation of cytokine activity in bone.
FUNCTIONAL HYPOPARATHYROIDISM AND PARATHYROID HORMONE END‐ORGAN RESISTANCE IN HUMAN MAGNESIUM DEFICIENCY
Evidence is provided for impaired parathyroid gland function in most of the magnesium deficient patients with hypocalcaemia, and the rapidity with which serum IPTH rose in response to magnesium therapy indicates that this may reflect a defect inParathyroid hormone (PTH) secretion rather than its biosynthesis.
Comparative study of alendronate versus etidronate for the treatment of Paget's disease of bone.
Alendronate appears to be a highly effective treatment for Paget's disease of bone that offers an important therapeutic advance over etidronate and had a safety profile similar to that of etidronsate.