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Galectin-3 Precipitates as a Pentamer with Synthetic Multivalent Carbohydrates and Forms Heterogeneous Cross-linked Complexes*
Galectin-3 is unique among the galectin family of animal lectins in its biological activities and structure. Most members of the galectin family including galectin-1 possess apoptotic activities,Expand
A Synthetic Conjugate Polysaccharide Vaccine Against Haemophilus influenzae Type b
The large-scale synthesis, pharmaceutical development, and clinical evaluation of a conjugate vaccine composed of a synthetic capsular polysaccharide antigen of Haemophilus influenzae type b (Hib) demonstrate that access to synthetic complex carbohydrate–based vaccines is feasible and provides a basis for further development of similar approaches for other human pathogens. Expand
Partial characterization of a cubic Bacillus phage.
Phage Bam35 is a new virus group which includes a phage of B. anthracis and four phages of gram-negative bacteria harboring drug-resistance plasmids, and contains DNA and, probably, lipids which seem to be located in the inner coat. Expand
Winter wheat hull (husk) is a valuable source for tricin, a potential selective cytotoxic agent.
The purified wheat husks tricin was found to be a selective potent inhibitor of two cancer cell lines of liver and pancreas, while having no side effects on normal cells, suggesting that tricIn could be considered as a potential candidate for pre-clinical trials as a chemopreventive agent. Expand
Determinant specificities of the groups B and C polysaccharides of Neisseria meningitidis.
The nature of the colominic acid-specific group B determinant was elucidated by a radioimmunoassay inhibition technique with the use of a series of linear alpha-(2----8)-linked oligomers of sialic acid as inhibitors. Expand
Syntheses and some applications of chemically defined multivalent glycoconjugates.
  • R. Roy
  • Chemistry, Medicine
  • Current opinion in structural biology
  • 1 October 1996
Classical multivalent neoglycoproteins have been widely used to study a great number of carbohydrate-protein interactions. The synthesis of other neoglycoconjugates with various shapes, valencies,Expand
Glycomimetics and glycodendrimers as high affinity microbial anti-adhesins.
Crystal structures of adhesin and lectin binding sites in complexes with oligosaccharide open the route for design and synthesis of glycomimetics, glycodendrimers, and glycopolymers that are able to block infection at an early stage. Expand
Binding of multivalent carbohydrates to concanavalin A and Dioclea grandiflora lectin. Thermodynamic analysis of the "multivalency effect".
Increases in K(a) values of the multivalent carbohydrates relative to monovalent analogs, known as the "multivalency effect," are shown to be due to more positive entropy (TDeltaS) contributions to binding of the former sugars. Expand
A guide into glycosciences: How chemistry, biochemistry and biology cooperate to crack the sugar code.
This review provides a didactic step-by-step survey of the concept of the sugar code and the way strategic combination of experimental approaches characterizes structure-function relationships, with resources for teaching. Expand
Engineering a Therapeutic Lectin by Uncoupling Mitogenicity from Antiviral Activity
It is demonstrated that a single amino-acid substitution in a banana lectin, replacing histidine 84 with a threonine, significantly reduces its mitogenicity, while preserving its broad-spectrum antiviral potency. Expand