Electrophoretic separation of rat skeletal muscle myosin heavy-chain isoforms.
- R. Talmadge, R. Roy
- BiologyJournal of applied physiology
- 1 November 1993
The percent composition of the four adult MHCs in rat soleus, medial gastrocnemius, diaphragm, and levator ani muscles by use of this procedure and Coomasie Blue staining is similar to that previously reported.
Muscle architecture of the human lower limb.
- T. Wickiewicz, R. Roy, P. Powell, V. Edgerton
- BiologyClinical Orthopaedics and Related Research
- 1 October 1983
The architectural features of the major knee extensors and flexors and ankle plantarflexors and dorsiflexors were determined in three human cadavers and grouped according to whether they showed a predilection for tension or velocity of shortening.
Predictability of skeletal muscle tension from architectural determinations in guinea pig hindlimbs.
- P. Powell, R. Roy, P. Kanim, M. A. Bello, V. Edgerton
- BiologyJournal of applied physiology: respiratory…
- 1 December 1984
A specific tension value of 22.5 N X cm-2 appears to be a reasonable value for all mixed muscles studied in the guinea pig hindlimb and can be used to estimate their Po.
Recovery of supraspinal control of stepping via indirect propriospinal relay connections after spinal cord injury
- G. Courtine, B. Song, M. Sofroniew
- Biology, PsychologyNature Network Boston
- 2008
It is shown that pronounced functional recovery can occur after severe SCI without the maintenance or regeneration of direct projections from the brain past the lesion and can be mediated by the reorganization of descending and propriospinal connections.
Architecture of the hind limb muscles of cats: Functional significance
- R. D. Sacks, R. Roy
- BiologyJournal of morphology
- 1 August 1982
Rations of wet weight to predicted maximal tetanic tension for each muscle and group were calculated to compare the relative priority of muscle force versus muscle length‐velocity for a given mass of muscle, suggesting that velocity and/or displacement is a priority for the hamstrings, whereas force is apriority for the quadriceps and lower leg muscles.
Rapid disuse and denervation atrophy involve transcriptional changes similar to those of muscle wasting during systemic diseases
- J. Sacheck, J. Hyatt, A. Goldberg
- BiologyThe FASEB Journal
- 1 January 2007
The atrophy associated with systemic catabolic states and following disuse involves similar transcriptional adaptations; and disuse atrophy proceeds through multiple phases corresponding to rapidly atrophying and atrophied muscles that involve distinct transcriptional patterns.
Physiological cross‐sectional area of human leg muscles based on magnetic resonance imaging
- T. Fukunaga, R. Roy, V. Edgerton
- BiologyJournal of Orthopaedic Research
- 1 November 1992
The soleus fibers were unusually short relative to the muscle volume, thus potentiating its force potential, and these data illustrate some of the major limitations in the use of ACSA measurements to predict the functional properties of a muscle.
Specific tension of human plantar flexors and dorsiflexors.
- T. Fukunaga, R. Roy, F. Shellock, J. Hodgson, V. Edgerton
- BiologyJournal of applied physiology
- 1996
The data suggest that factors other than PCSA contribute to the force output potential of ankle plantar flexors and dorsiflexors in humans.
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input
- G. Courtine, Y. Gerasimenko, V. Edgerton
- BiologyNature Neuroscience
- 1 October 2009
It is proposed that, in the absence of supraspinal input, spinal locomotion can emerge from a combination of central pattern-generating capability and the ability of these spinal circuits to use sensory afferent input to control stepping.
Apoptosis: a mechanism contributing to remodeling of skeletal muscle in response to hindlimb unweighting.
- D. Allen, J. Linderman, V. Edgerton
- BiologyAmerican Journal of Physiology
- 1 August 1997
The data suggest that 1) "programmed nuclear death" contributes to the elimination of myonuclei and/or satellite cells from atrophying fibers, and 2) GH/IGF-I administration plus muscle loading ameliorates the apoptosis associated with hindlimb unloading.
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