R. Roque

Publications52
h-index19
Citations1,281
Highly Influential Citations34
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Tissue transglutaminase expression and activity in normal and glaucomatous human trabecular meshwork cells and tissues.
TLDR
Results indicate that TGM2 may play an important role in the pathogenesis of glaucoma by cross-linking ECM proteins such as FN and thus making the ECM more resistant to degradation.
Serum deprivation induces apoptotic cell death of transformed rat retinal ganglion cells via mitochondrial signaling pathways.
TLDR
It is indicated that serum withdrawal induces apoptotic cell death in RGC-5 cells via mitochondrial pathways, leading to the speculation that growth factor deprivation arising from blockade of retrograde transport of neurotrophins may involve similar mechanism(s) of retinal ganglion cellDeath in glaucoma.
Cultured Müller cells have high levels of epidermal growth factor receptors.
TLDR
A functional role for EGF in Müller cell proliferation in retinal disease is supported, as evidenced by 3H-thymidine uptake studies and nonlinear-regression analyses.
Glutamate stimulates neurotrophin expression in cultured Müller cells.
3D‐model of adult cardiac stem cells promotes cardiac differentiation and resistance to oxidative stress
TLDR
It is suggested that cardiospheres are potentially useful for delivering functional stem cells to the damaged heart by showing strong resistance to elevated concentrations of hydrogen peroxide in culture and survived subcutaneous injections without undergoing neoplastic transformation up to 3 weeks post‐transplantation.
Human Müller cells express VEGF183, a novel spliced variant of vascular endothelial growth factor.
TLDR
The expression of the novel isoform V EGF 183 in human Müller cells, its variable tissue expression, and its modulation by hypoxia may provide another pathway for VEGF induction of angiogenesis in the retina.
Microglia-derived Pronerve Growth Factor Promotes Photoreceptor Cell Death via p75 Neurotrophin Receptor*
TLDR
The study shows that a ∼32 kDa pro-NGF protein released by activated retinal microglia promoted degeneration of cultured photoreceptor cells and suggests that defective post-translational processing of NGF might be involved in photorecept cell loss in retinal dystrophy.
Vascular endothelial growth factor is increased following coronary artery occlusion in the dog heart
TLDR
This study investigated the expression of the various isoforms of VEGF in normal and ischemic dog heart tissues using Reverse transcription-Polymerase chain reaction, Ribonuclease Protection Assay and Western blotting and showed that the nucleotide sequences of dog V EGF were highly homologous to human VEGf especially in the c-terminal region spanning exons 5-8.
Microglial cells invade the outer retina as photoreceptors degenerate in Royal College of Surgeons rats.
TLDR
The findings suggest that phagocytic cells during the early stages of dystrophy in RCS rat retinas are derived from resident microglial cells, not from peripheral macrophages, which suggests that they may play a major role in photoreceptor cell death in the dystrophic retina.
Retina-derived microglial cells induce photoreceptor cell death in vitro
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