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The Sequence of the Human Genome
Comparative genomic analysis indicates vertebrate expansions of genes associated with neuronal function, with tissue-specific developmental regulation, and with the hemostasis and immune systems are indicated.
REBASE—a database for DNA restriction and modification: enzymes, genes and genomes
REBASE is a comprehensive and fully curated database of information about the components of restriction-modification (RM) systems. It contains fully referenced information about recognition and…
NEBcutter: a program to cleave DNA with restriction enzymes
NEBcutter, version 1.0, is a program available via a web server that will accept an input DNA sequence and produce a comprehensive report of the restriction enzymes that will cleave the sequence.
A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes.
A nomenclature is described for restriction endonucleases, DNA methyltransferases, homing endonucleases and related genes and gene products. It provides explicit categories for the many different…
REBASE—enzymes and genes for DNA restriction and modification
All newly sequenced genomes are analyzed for the presence of putative restriction systems and these data are included within the REBASE.
Homing endonucleases: keeping the house in order.
The evolution of homing endonucleases is considered, both at the structure-function level and in terms of their persistence in widely divergent biological systems.
The Epigenomic Landscape of Prokaryotes
The results reveal the pervasive presence ofDNA methylation throughout the prokaryotic kingdoms, as well as the diversity of sequence specificities and potential functions of DNA methylation systems.
An amazing sequence arrangement at the 5′ ends of adenovirus 2 messenger RNA
The DNA (cytosine-5) methyltransferases
The reaction pathway has suddenly become more complicated because of the base-flipping and much remains to be learned about the DNA recognition elements in the family members for which structural information is not yet available.
REBASE—restriction enzymes and DNA methyltransferases
An extensive analysis is included of the restriction–modification systems that are predicted to be present in the sequenced bacterial and archaeal genomes from GenBank.