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Follow-up report on the diagnosis of diabetes mellitus.
In 1997, an International Expert Committee was convened to reexamine the classification and diagnostic criteria of diabetes, which were based on the 1979 publication of the National Diabetes Data… Expand
Meal Simulation Model of the Glucose-Insulin System
- C. D. Man, R. Rizza, C. Cobelli
- Medicine, Computer Science
- IEEE Transactions on Biomedical Engineering
- 17 September 2007
A simulation model of the glucose-insulin system in the postprandial state can be useful in several circumstances, including testing of glucose sensors, insulin infusion algorithms and decision… Expand
Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes.
Type 2 diabetes is characterized by impaired insulin secretion. Some but not all studies suggest that a decrease in beta-cell mass contributes to this. We examined pancreatic tissue from 124… Expand
β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes
Type 2 diabetes is characterized by impaired insulin secretion. Some but not all studies suggest that a decrease in β-cell mass contributes to this. We examined pancreatic tissue from 124 autopsies:… Expand
Report of the expert committee on the diagnosis and classification of diabetes mellitus.
the growth of knowledge regarding the etiology and pathogenesis of diabetes has led many individuals and groups in the diabetes community to express the need for a revision of the nomenclature,… Expand
Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity.
Insulin resistance increases and muscle oxidative capacity decreases during aging, but lifestyle changes-especially physical activity-may reverse these trends. Here we report the effect of a 16-week… Expand
DHEA in elderly women and DHEA or testosterone in elderly men.
BACKGROUND Dehydroepiandrosterone (DHEA) and testosterone are widely promoted as antiaging supplements, but the long-term benefits, as compared with potential harm, are unknown. METHODS We… Expand
β-Cell Replication Is the Primary Mechanism Subserving the Postnatal Expansion of β-Cell Mass in Humans
OBJECTIVE— Little is known about the capacity, mechanisms, or timing of growth in β-cell mass in humans. We sought to establish if the predominant expansion of β-cell mass in humans occurs in early… Expand
GIM, Simulation Software of Meal Glucose—Insulin Model
- C. Dalla Man, D. Raimondo, R. Rizza, C. Cobelli
- Medicine, Computer Science
- Journal of diabetes science and technology
- 1 May 2007
Background: A simulation model of the glucose—insulin system in normal life conditions can be very useful in diabetes research, e.g., testing insulin infusion algorithms and decision support systems… Expand
Dose-response characteristics for effects of insulin on production and utilization of glucose in man.
To determine the dose-response characteristics for the effects of insulin on glucose production, glucose utilization, and overall glucose metabolism in normal man, 15 healthy subjects were infused… Expand