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Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology.
TLDR
The introduction of a widely acceptable clinical subclassification is strongly advocated, which would allow detailed correlations among serotype, genotype and clinical phenotype to be examined and confirmed in independent cohorts of patients and, thereby, provide a vital foundation for future work.
Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial.
TLDR
Among patients with a history of colorectal adenomas, the use of rofecoxib was associated with an increased cardiovascular risk, and cardiovascular mortality was similar in the two groups.
Dysplasia in inflammatory bowel disease: standardized classification with provisional clinical applications.
TLDR
A classification system for the epithelial changes that occur in ulcerative colitis was developed, which should be applicable to other forms of inflammatory bowel disease as well and makes use of standardized terminology, addresses specific problem areas, and offers practical solutions.
The Vienna classification of gastrointestinal epithelial neoplasia
TLDR
The differences between Western and Japanese pathologists in the diagnostic classification of gastrointestinal epithelial neoplastic lesions can be resolved largely by adopting the proposed terminology, which is based on cytological and architectural severity and invasion status.
Interstitial cells of Cajal as precursors of gastrointestinal stromal tumors.
TLDR
CD34 was found to colocalize with vimentin (Vim) and the Kit-positive networks of cells within and around neural plexi, indicating that ICC can be Vim- and CD34-positive.
Quality in the technical performance of colonoscopy and the continuous quality improvement process for colonoscopy: recommendations of the U.S. Multi-Society Task Force on Colorectal Cancer
TLDR
This research presents a novel and scalable approach to Gastroenterology that aims to provide real-time information about the immune system’s response to gluten during the first trimester of pregnancy.
Tumor budding in colorectal carcinoma: time to take notice
TLDR
The morphology of tumor budding and its relationship to other potentially important features of the invasive front are described and the challenges posed by a lack of data to allow standardization with respect to the qualitative and quantitative criteria used to define budding are highlighted.
A reproducible grading scale for histological assessment of inflammation in ulcerative colitis
TLDR
A histological activity system was developed for ulcerative colitis that showed good reproducibility and modest agreement with the endoscopic grading system which it complemented and has potential value both clinically and in clinical trials.
Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE): Determining Therapeutic Goals for Treat-to-Target
TLDR
Evidence- and consensus-based recommendations for selecting the goals for treat-to-target strategies in patients with IBD are made available and future studies are needed to determine how these targets will change disease course and patients’ quality of life.
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