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Involvement of NADPH Oxidase Isoforms and Src Family Kinases in CD95-dependent Hepatocyte Apoptosis*
CD95 ligand (CD95L) triggers a rapid formation of reactive oxygen species (ROS) as an upstream event of CD95 activation and apoptosis induction in rat hepatocytes. This ROS response was sensitive toExpand
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Intercellular communication via gap junctions in activated rat hepatic stellate cells.
BACKGROUND AND AIMS Gap junctional communication was studied in quiescent and activated hepatic stellate cells. METHODS Connexin expression and intercellular dye transfer were studied in ratExpand
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The G‐protein coupled bile salt receptor TGR5 is expressed in liver sinusoidal endothelial cells
Sinusoidal endothelial cells (SEC) constitute a permeable barrier between hepatocytes and blood. SEC are exposed to high concentrations of bile salts from the enterohepatic circulation. Whether SECExpand
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Hypoosmotic swelling and ammonia increase oxidative stress by NADPH oxidase in cultured astrocytes and vital brain slices
The role of NADPH oxidase (NOX) and the regulatory subunit p47phox for hypoosmotic ROS generation was studied in cultured rat astrocytes and brain slices of wilde type and p47phox knock‐out mice.Expand
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Selenoprotein P expression is controlled through interaction of the coactivator PGC‐1α with FoxO1a and hepatocyte nuclear factor 4α transcription factors
Selenoprotein P (SeP), the major selenoprotein in plasma, is produced mainly by the liver, although SeP expression is detected in many organs. Recently, we reported stimulation of SeP promoterExpand
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Prevention of bile acid–induced apoptosis by betaine in rat liver
Bile acid–induced apoptosis plays an important role in the pathogenesis of cholestatic liver disease, and its prevention is of therapeutic interest. The effects of betaine were studied onExpand
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Chronic liver disease is triggered by taurine transporter knockout in the mouse
Taurine is an abundant organic osmolyte with antioxidant and immunomodulatory properties. Its role in the pathogenesis of chronic liver disease is unknown. The liver phenotype was studied in taurineExpand
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Endosomal Acidification and Activation of NADPH Oxidase Isoforms Are Upstream Events in Hyperosmolarity-induced Hepatocyte Apoptosis*
Hyperosmotic exposure of rat hepatocytes induced a rapid oxidative-stress(ROS) response as an upstream signal for proapoptotic CD95 activation. This study shows that hyperosmotic ROS formationExpand
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Bile salt-induced apoptosis involves NADPH oxidase isoform activation.
BACKGROUND & AIMS Hydrophobic bile salts trigger a rapid oxidative stress response as an upstream event of CD95 activation and hepatocyte apoptosis. METHODS The underlying mechanisms were studiedExpand
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Bile salt-induced hepatocyte apoptosis involves epidermal growth factor receptor-dependent CD95 tyrosine phosphorylation.
BACKGROUND & AIMS Hydrophobic bile acids induce CD95-dependent hepatocyte apoptosis. METHODS The mechanisms of bile acid-induced CD95 activation were studied in 24-hour cultured rat hepatocytes, inExpand
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