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Topiramate placebo-controlled dose-ranging trial in refractory partial epilepsy using 200-, 400-, and 600-mg daily dosages
We conducted a randomized double-blind comparison of three doses of the novel antiepileptic drug (AED) topiramate (200, 400, and 600 mg/day) and placebo as adjunctive therapy in patients withExpand
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Topiramate placebo-controlled dose-ranging trial in refractory partial epilepsy using 600-, 800-, and 1,000-mg daily dosages
We conducted a multicenter, double-blind, randomized, parallel, placebo-controlled trial in 190 patients to evaluate the safety and efficacy of three dosages of topiramate (600, 800, and 1,000Expand
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A double-blind, randomized trial of topiramate in Lennox–Gastaut syndrome
Objective: To evaluate the efficacy and safety of topiramate as adjunctive therapy for Lennox–Gastaut syndrome in a multicenter, double-blind, placebo-controlled trial. Background: ConventionalExpand
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A randomized, placebo-controlled study of topiramate in primary generalized tonic-clonic seizures
Background and Objective: Topiramate is effective as adjunctive treatment of partial-onset seizures in adults. The efficacy and safety of topiramate as adjunctive therapy for the treatment of primaryExpand
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Topiramate Monotherapy for Partial Onset Seizures
Summary: Purpose: Evaluation of topiramate (TPM) as monotherapy in patients with uncontrolled partial onset seizures.
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Topiramate as Add‐On Therapy: Pooled Analysis of Randomized Controlled Trials in Adults
Purpose: Six double‐blind, placebo‐controlled trials were conducted with topiramate (TPM) initiated as adjunctive therapy in adults with treatment‐resistant partial‐onset seizures with or withoutExpand
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Double‐Blind, Placebo‐Controlled Trial of Topiramate (600 mg Daily) for the Treatment of Refractory Partial Epilepsy
Summary: Purpose: We wished to evaluate adjunctive therapy for partial‐onset seizures with topiramate (TPM) for efficacy and safety in a double‐blind, placebo‐controlled, randomized, parallel‐groupExpand
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Double‐Blind, Placebo‐Controlled Trial of Topiramate as Add‐on Therapy in Patients with Refractory Partial Seizures
Summary: In a double‐blind, randomized, parallel‐group trial, we compared topiramate (TPM) with placebo as addon therapy in patients with refractory partial epilepsy. TPM was titrated either to theExpand
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A double-blind, randomized trial of topiramate as adjunctive therapy for partial-onset seizures in children
Objective: To evaluate the efficacy and safety of topiramate 6 mg/kg/day in children (age 2 to 16 years) as adjunctive therapy for uncontrolled partial-onset seizures with or without secondarilyExpand
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A study of topiramate pharmacokinetics and tolerability in children with epilepsy.
The pharmacokinetic and safety profile of topiramate as adjunctive therapy was assessed in pediatric patients with epilepsy in an open-label, 4-week, single-center study. Six children from each ofExpand
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