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Intravenous infusion of peptide YY(3-36) potently inhibits food intake in rats.
Peptide YY (3-36) [PYY (3-36)] is postulated to act as a hormonal signal from the gut to the brain to inhibit food intake and gastric emptying. A mixed-nutrient meal produces a prolonged 2-3 hExpand
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Intravenous infusion of glucagon-like peptide-1 potently inhibits food intake, sham feeding, and gastric emptying in rats.
Glucagon-like peptide-1(7-36)-amide (GLP-1) is postulated to act as a hormonal signal from gut to brain to inhibit food intake and gastric emptying. A mixed-nutrient meal produces a 2 to 3-h increaseExpand
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Comparison of the inhibitory effects of PYY(3-36) and PYY(1-36) on gastric emptying in rats.
We compared the effects of the two molecular forms of the brain-gut peptide YY (PYY), PYY(1-36) and PYY(3-36), on gastric emptying. Unanesthetized rats received 20-min intravenous infusions of ratExpand
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Abdominal vagal mediation of the satiety effects of exogenous and endogenous cholecystokinin in rats.
  • R. Reidelberger
  • Biology, Medicine
  • The American journal of physiology
  • 1 December 1992
The hypothesis that peripherally administered cholecystokinin C-terminal octapeptide (CCK-8) and endogenous CCK act by the same abdominal vagal mechanism to produce satiety was tested by injectingExpand
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Abdominal vagal mediation of the satiety effects of CCK in rats.
CCK type 1 (CCK1) receptor antagonists differing in blood-brain barrier permeability were used to test the hypothesis that satiety is mediated in part by CCK action at CCK1 receptors on vagal sensoryExpand
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Long-term cannulation model for blood sampling and intragastric infusion in the rat.
An improved methodology is described for long-term venous and gastric cannulation in the rat. The long-term efficacy of the cannulas for blood sampling and intragastric infusion of liquid diet wasExpand
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Brain regions where cholecystokinin suppresses feeding in rats
The gut-brain peptide, cholecystokinin (CCK), inhibits food intake when injected either systemically or within the brain. To determine whether CCK's effect in the brain is anatomically specific,Expand
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Cholecystokinin and control of food intake.
Two mechanisms have been suggested for the inhibitory effect of cholecystokinin on food intake: a central action of brain cholecystokinin on the brain feeding system, and a peripheral, presumablyExpand
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Effect of nutrient density and composition of liquid meals on gastric emptying in feeding rats.
Rats were fitted with gastric cannulas to determine gastric emptying rates of liquid test meals after a 16-h fast. They were allowed to drink [14C]polyethylene glycol (PEG) Vivonex High NitrogenExpand
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Effects of duodenal and distal ileal infusions of glucose and oleic acid on meal patterns in rats.
The mechanisms mediating the anorexic effects of nutrients in the proximal and distal small intestine are not clearly understood. We determined the dose-dependent effects of duodenal and distal ilealExpand
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