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Assessment of glycosaminoglycan concentration in vivo by chemical exchange-dependent saturation transfer (gagCEST)
- W. Ling, R. Regatte, G. Navon, A. Jerschow
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences
- 19 February 2008
Glycosaminogycans (GAGs) are involved in numerous vital functions in the human body. Mapping the GAG concentration in vivo is desirable for the diagnosis and monitoring of a number of diseases such… Expand
Biomedical applications of sodium MRI in vivo
In this article we present an up‐to‐date overview of the potential biomedical applications of sodium magnetic resonance imaging (MRI) in vivo. Sodium MRI is a subject of increasing interest in… Expand
T1rho relaxation mapping in human osteoarthritis (OA) cartilage: comparison of T1rho with T2.
- R. Regatte, S. V. Akella, J. Lonner, J. Kneeland, R. Reddy
- Journal of magnetic resonance imaging : JMRI
PURPOSE To quantify the spin-lattice relaxation time in the rotating frame (T1rho) in various clinical grades of human osteoarthritis (OA) cartilage specimens obtained from total knee replacement… Expand
A method for estimating intracellular sodium concentration and extracellular volume fraction in brain in vivo using sodium magnetic resonance imaging
In this feasibility study we propose a method based on sodium magnetic resonance imaging (MRI) for estimating simultaneously the intracellular sodium concentration (C1, in mM) and the extracellular… Expand
Proteoglycan depletion-induced changes in transverse relaxation maps of cartilage: comparison of T2 and T1rho.
- R. Regatte, S. V. Akella, Arijitt Borthakur, J. Kneeland, R. Reddy
- Academic radiology
- 1 December 2002
RATIONALE AND OBJECTIVES The authors performed this study to (a) measure changes in T2 relaxation rates, signal-to-noise ratio (SNR), and contrast with sequential depletion of proteoglycan in… Expand
Proteoglycan loss in human knee cartilage: quantitation with sodium MR imaging--feasibility study.
The feasibility of using sodium magnetic resonance (MR) imaging to detect proteoglycan loss in early-stage osteoarthritis is evaluated. Fixed charge density (FCD) maps were calculated from sodium MR… Expand
Ultra‐high‐field MRI of the musculoskeletal system at 7.0T
High‐field (3T) and ultra‐high‐field (UHF, 7T and above) systems are increasingly being used to explore potential musculoskeletal applications because they provide a high intrinsic signal‐to‐noise… Expand
Reduction of residual dipolar interaction in cartilage by spin‐lock technique
- S. V. Akella, R. Regatte, A. Wheaton, Arijitt Borthakur, R. Reddy
- Chemistry, Medicine
- Magnetic resonance in medicine
- 1 November 2004
The influence of radiofrequency (RF) spin‐lock pulse on the laminar appearance of articular cartilage in MR images was investigated. Spin‐lock MRI experiments were performed on bovine cartilage plugs… Expand
3D-T1rho-relaxation mapping of articular cartilage: in vivo assessment of early degenerative changes in symptomatic osteoarthritic subjects.
RATIONALE AND OBJECTIVES To determine the in vivo feasibility of quantifying early degenerative changes in patellofemoral joint of symptomatic human knee using spin-lattice relaxation time in the… Expand
In vivo proton MR three-dimensional T1rho mapping of human articular cartilage: initial experience.
The purpose of this study was to demonstrate the feasibility of computing three-dimensional relaxation maps of spin-lattice relaxation time in the rotating frame (T1rho) from in vivo magnetic… Expand