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MR1 presents microbial vitamin B metabolites to MAIT cells
Antigen-presenting molecules, encoded by the major histocompatibility complex (MHC) and CD1 family, bind peptide- and lipid-based antigens, respectively, for recognition by T cells.Expand
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T-cell activation by transitory neo-antigens derived from distinct microbial pathways
T cells discriminate between foreign and host molecules by recognizing distinct microbial molecules, predominantly peptides and lipids. Riboflavin precursors found in many bacteria and yeast alsoExpand
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Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells
Generation of antigen-loaded MR1 tetramers that specifically stain MAIT cells identifies heterogeneity in phenotypes and TCR repertoires in humans and mice.
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Recognition of vitamin B metabolites by mucosal-associated invariant T cells.
The mucosal-associated invariant T-cell antigen receptor (MAIT TCR) recognizes MR1 presenting vitamin B metabolites. Here we describe the structures of a human MAIT TCR in complex with human MR1Expand
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A molecular basis underpinning the T cell receptor heterogeneity of mucosal-associated invariant T cells
A novel MAIT cell antagonist, Ac-6-FP, stabilizes MR1 and can inhibit MAIT cell activation with the flexible TCR β-chain serving to fine-tune the affinity of the TCR for antigen-MR1 complexes.
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Structural insight into MR1-mediated recognition of the mucosal associated invariant T cell receptor
Crystal structure and mutagenesis analyses suggest a MAIT TCR–MR1 docking mode distinct from the NKT TCR-CD1d docking mode.
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Immune Mediators in Osteoarthritis: Infrapatellar Fat Pad-Infiltrating CD8+ T Cells Are Increased in Osteoarthritic Patients with Higher Clinical Radiographic Grading
Osteoarthritis is a condition of joint failure characterized by many pathologic changes of joint-surrounding tissues. Many evidences suggest the role of both innate and adaptive immunity thatExpand
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Structural insight into MR 1-mediated recognition of the mucosal associated invariant T cell receptor
The Rockefeller University Press $30.00 J. Exp. Med. Vol. 209 No. 4 761-774 www.jem.org/cgi/doi/10.1084/jem.20112095 761 Antigen (Ag)-specific immunity is orchestrated by T cells that determine theExpand
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Monitoring Anti-Pythium insidiosum IgG Antibodies and (1→3)-β-d-Glucan in Vascular Pythiosis
Despite aggressive treatment, vascular pythiosis has a mortality rate of 40%. This is due to delays in diagnosis and a lack of effective monitoring tools. ABSTRACT Despite aggressive treatment,Expand
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Asthma Research Performance in Asia-Pacific: A Bibliometric Analysis by Searching PubMed Database
Background and Objective. Countries in the Asia-Pacific region have experienced an increase in the prevalence of asthma, and they have been actively involved in asthma research recently. This studyExpand
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