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Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors.
Cannabinoids, including the endogenous ligand arachidonyl ethanolamide (anandamide), elicit not only neurobehavioral but also cardiovascular effects. Two cannabinoid receptors, CB1 and CB2, have beenExpand
Selective ligands and cellular effectors of a G protein-coupled endothelial cannabinoid receptor.
The cannabinoid analog abnormal cannabidiol [abn-cbd; (-)-4-(3-3,4-trans-p-menthadien-[1,8]-yl)-olivetol] does not bind to CB(1) or CB(2) receptors, yet it acts as a full agonist in relaxing ratExpand
A biosynthetic pathway for anandamide
  • J. Liu, L. Wang, +8 authors G. Kunos
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 5 September 2006
The endocannabinoid arachidonoyl ethanolamine (anandamide) is a lipid transmitter synthesized and released “on demand” by neurons in the brain. Anandamide is also generated by macrophages where itsExpand
Cannabinoid structure-activity relationships: correlation of receptor binding and in vivo activities.
Although a receptor exists for cannabinoid drugs, it is uncertain which pharmacological actions this receptor mediates. This structure-activity relationship investigation was initiated to determineExpand
Behavioral, biochemical, and molecular modeling evaluations of cannabinoid analogs
Numerous cannabinoids have been synthesized that are extremely potent in all of the behavioral assays conducted in our laboratory. An important feature in increasing potency has been the substitutionExpand
The pharmacological activity of anandamide, a putative endogenous cannabinoid, in mice.
The arachidonic acid derivative anandamide (arachidonylethanolamide) has been isolated from porcine brain and has been shown to bind competitively to the cannabinoid receptor. Although theExpand
Levels, metabolism, and pharmacological activity of anandamide in CB(1) cannabinoid receptor knockout mice: evidence for non-CB(1), non-CB(2) receptor-mediated actions of anandamide in mouse brain.
Anandamide [arachidonylethanolamide (AEA)] appears to be an endogenous agonist of brain cannabinoid receptors (CB(1)), yet some of the neurobehavioral effects of this compound in mice are unaffectedExpand
Sensitivity to Δ9-tetrahydrocannabinol is selectively enhanced in beta-arrestin2−/− mice
Little is known about the roles of &bgr;-arrestins in the regulation of brain CB1 cannabinoid receptors. This study investigated the role of &bgr;-arrestin2 in cannabinoid behavioral effects usingExpand
Evaluation of the role of the arachidonic acid cascade in anandamide's in vivo effects in mice.
The pharmacological profiles of the endocannabinoid anandamide and exogenous cannabinoids (e.g., Delta9-tetrahydrocannabinol) are similar, but not exactly the same. One notable difference is thatExpand
Cardiovascular effects of 2-arachidonoyl glycerol in anesthetized mice.
Cannabinoids, including the endogenous ligand anandamide, elicit pronounced hypotension and bradycardia through the activation of CB1 cannabinoid receptors. A second endogenous cannabinoid,Expand