• Publications
  • Influence
A colorimetric microassay for the detection of agents that interact with DNA.
The feasibility of using the assay for detecting DNA-active compounds in fermentation extracts was assessed, and the activities of reference compounds in the methyl green assay and an ethidium bromide displacement method were compared. Expand
Calbistrins, novel antifungal agents produced by Penicillium restrictum. II. Isolation and elucidation of structure.
NMR studies revealed that the calbistrins each contain a carboxylic acid conjugated tetraene attached through an aliphatic ester linkage to a hexahydronaphthalene system. Expand
Two distinct receptors account for recognition of maleyl-albumin in human monocytes during differentiation in vitro.
It is reported that human monocytes express a second cellular surface receptor for maleyl-albumin that is distinct from the scavenger receptor, a useful adjunct to studies of cellular events mediated by the scavengers. Expand
Macquarimicins, microbial metabolites from Micromonospora. I. Discovery, taxonomy, fermentation and biological properties.
A novel series of microbial metabolites were discovered in fermentation broths of two soil isolates identified as strains of Micromonospora chalcea, and macquarimicin B has inhibitory activity against the leukemia cell line P-388. Expand
N-cyclopropyltryptamines, potent monoamine oxidase inhibitors.
Antifungal drug targets: Candida secreted aspartyl protease and fungal wall beta-glucan synthesis.
The study of fungal biochemistry, physiology, and genetics has undergone a resurgence to new heights of activity, providing a framework on which to build drug discovery programs in several new areas, two of which will be discussed in detail: the biology of Candida albicans secreted aspartyl protease with respect to inhibitor discovery, evaluation, and possible clinical utility. Expand
Pacidamycins, a novel series of antibiotics with anti-Pseudomonas aeruginosa activity. III. Microbiologic profile.
The pacidamycins were inactive against P. aeruginosa in mouse protection test and the frequency of resistance to these compounds was less than 3.5 x 10(-6). Expand
5-N-acetylardeemin, a novel heterocyclic compound which reverses multiple drug resistance in tumor cells. I. Taxonomy and fermentation of the producing organism and biological activity.
The ardeemins are a new family of secondary metabolites produced by submerged fermentation of a fungus which was isolated from a soil sample collected in Brazil and potentiated the cytotoxicity of the anticancer agent vinblastine in multidrug resistant human tumor cells. Expand