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Molecular enzymology of carnitine transfer and transport.
TLDR
The kinetic and chemical mechanisms of the carnitine acyltransferases are discussed in relation to the different inhibitors under study for their potential to control diseases of lipid metabolism.
Methylene blue and serotonin toxicity: inhibition of monoamine oxidase A (MAO A) confirms a theoretical prediction
TLDR
Methylene blue (methylthionium chloride, MB), a redox dye in clinical use, has been reported to precipitate ST in patients using SSRI and was assessed for MAO inhibition and so for its potential to precipitates ST.
Inhibition of monoamine oxidase A by beta-carboline derivatives.
TLDR
Harmine, 2-methylharminium, 2,9-dimethylharminum, and harmaline were the most effective inhibitors of the purified MAO A, with low Ki values of 5, 69, 15, and 48 nM, respectively.
Inhibition of Monoamine Oxidase A by β-Carboline Derivatives
TLDR
Harmine, 2-methylharminium, 2,9-dimethylharminum, and harmaline were the most effective inhibitors of the purified MAO A, with lowKivalues of 5, 69, 15, and 48 nM, respectively.
Carnitine acyltransferases and their influence on CoA pools in health and disease.
TLDR
The location, properties of and deficiencies in the carnitine acyltransferases are described in relation to their influence on the CoA pools in the cell and, hence, on metabolism.
Biochemical Events in the Development of Parkinsonism Induced by 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine
TLDR
Rapid progress in clarifying the individual steps leading to the neuropathological symptoms has been remarkable and a plausible mechanistic picture has emerged so that the time seems right to review current knowledge of the individual biochemical events involved in the expression of the selective neurotoxicity of MPTP.
Role of carnitine and carnitine palmitoyltransferase as integral components of the pathway for membrane phospholipid fatty acid turnover in intact human erythrocytes.
TLDR
Investigation of the role of carnitine palmitoyltransferase in erythrocyte membrane phospholipid fatty acid turnover supports the existence of an acyl-L-carnitine pool, in equilibrium with the ac-CoA pool, which serves as a reservoir of activated acyl groups.
Carnitine, mitochondrial function and therapy.
TLDR
This review aims to rationalise the extensive range of experimental and clinical data obtained through the pharmacological use of L-carnitine and its short-chain acylesters, over the past two decades, in terms of the basic biochemical mechanisms involved in the effects of carnitine on the various cellular acyl-CoA pools in health and disease.
Energy-dependent uptake of N-methyl-4-phenylpyridinium, the neurotoxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, by mitochondria.
TLDR
This paradox has now been resolved by the discovery of an energized uptake system forMPP+ in mitochondria which rapidly concentrates MPP+ to very high concentrations in the mitochondria at micromolar external concentrations.
In vitro effects of acetaminophen metabolites and analogs on the respiration of mouse liver mitochondria.
TLDR
The quinone derivatives are the best inhibitors, with the onset of inhibition dependent on active respiration, suggesting interaction of these compounds with oxidized components of the electron transport chain.
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