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Inhibition of cancer cell invasion by cannabinoids via increased expression of tissue inhibitor of matrix metalloproteinases-1.
  • R. Ramer, B. Hinz
  • Biology, Medicine
  • Journal of the National Cancer Institute
  • 2 January 2008
BACKGROUND Cannabinoids, in addition to having palliative benefits in cancer therapy, have been associated with anticarcinogenic effects. Although the antiproliferative activities of cannabinoidsExpand
COX-2 and PPAR-γ Confer Cannabidiol-Induced Apoptosis of Human Lung Cancer Cells
The antitumorigenic mechanism of cannabidiol is still controversial. This study investigates the role of COX-2 and PPAR-γ in cannabidiol's proapoptotic and tumor-regressive action. In lung cancerExpand
Decrease of Plasminogen Activator Inhibitor-1 May Contribute to the Anti-Invasive Action of Cannabidiol on Human Lung Cancer Cells
ABSTRACTPurposeUsing human lung cancer cells, we evaluated the involvement of plasminogen activator inhibitor-1 (PAI-1) in the anti-invasive action of cannabidiol, a non-psychoactiveExpand
Up-Regulation of Cyclooxygenase-2 Expression Is Involved in R(+)-Methanandamide-Induced Apoptotic Death of Human Neuroglioma Cells
Cannabinoids have been implicated in the reduction of glioma growth. The present study investigated a possible relationship between the recently shown induction of cyclooxygenase (COX)-2 expressionExpand
Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule‐1
Cannabinoids inhibit cancer cell invasion via increasing tissue inhibitor of matrix metalloproteinases‐1 (TIMP‐1). This study investigates the role of intercellular adhesion molecule‐1 (ICAM‐1)Expand
Prostaglandin E2 induces cyclooxygenase-2 expression in human non-pigmented ciliary epithelial cells through activation of p38 and p42/44 mitogen-activated protein kinases.
Prostaglandins (PGs) have been implicated in lowering intraocular pressure (IOP). A possible role of cyclooxygenase-2 (COX-2) in this process was emphasized by findings showing impaired COX-2Expand
Anti‐tumour actions of cannabinoids
The endocannabinoid system has emerged as an important target for the treatment of many diverse diseases. In addition to the well‐established palliative effects of cannabinoids in cancer therapy,Expand
Antitumorigenic Effects of Cannabinoids beyond Apoptosis
According to the World Health Organization, the cases of death caused by cancer will have been doubled until the year 2030. By 2010, cancer is expected to be the number one cause of death. Therefore,Expand
R(+)-Methanandamide-Induced Apoptosis of Human Cervical Carcinoma Cells Involves A Cyclooxygenase-2-Dependent Pathway
PurposeCannabinoids have received renewed interest due to their antitumorigenic effects. Using human cervical carcinoma cells (HeLa), this study investigates the role of cyclooxygenase-2 (COX-2) inExpand
Aceclofenac spares cyclooxygenase 1 as a result of limited but sustained biotransformation to diclofenac
  • B. Hinz, T. Rau, +4 authors K. Brune
  • Chemistry, Medicine
  • Clinical pharmacology and therapeutics
  • 1 September 2003
The mechanism of action of aceclofenac is currently unclear. This study investigated whether biotransformation to metabolites (4′‐hydroxy‐aceclofenac, diclofenac, 4′‐hydroxy‐diclofenac) contributesExpand