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Essential role for proteinase-activated receptor-2 in arthritis.
TLDR
It is demonstrated that proteinase-activated receptor-2 (PAR-2) plays a pivotal role in mediating chronic inflammation, thereby identifying a novel and important therapeutic target for the management of chronic inflammatory diseases such as rheumatoid arthritis. Expand
Inhibition of the ubiquitin-proteasome system in Alzheimer's disease.
TLDR
It is shown that Ub(+1) is an efficient substrate for polyubiquitination in vitro and in transfected human cells and could result in dominant inhibition of the Ub-proteasome system, leading to neuropathologic consequences in aging brain. Expand
The antimicrobial antiproteinase elafin binds to lipopolysaccharide and modulates macrophage responses.
TLDR
It is demonstrated here that the antimicrobial/anti-neutrophil elastase full-length elafin (FL-EL) is able to bind both smooth and rough forms of LPS, and the N-terminus was shown to binds both forms ofLPS more avidly. Expand
Hypocholesterolemic effect of barley foods on healthy men
TLDR
A regression model for predicting the effects of wheat and barley diets based on pre-treatment values is presented, and type of dietary fibre, soluble or insoluble, and concentration of serum cholesterol are considerations in predicting the degree of hypocholesterolaemic effect of cereal grains. Expand
Mg2+ and ATP or adenosine 5′-[γ-thio]-triphosphate (ATPγS) enhances intrinsic fluorescence and induces aggregation which increases the activity of spinach Rubisco activase
Abstract ATP and Mg 2+ caused a transient increase in the intrisinc fluorescence of Rubisco activase which was inhibited by the presence of ADP. Only minor changes in fluorescence were observed withExpand
Synthetic, structural and biological studies of the ubiquitin system: the total chemical synthesis of ubiquitin.
TLDR
The small protein ubiquitin (76 amino acids) has been synthesized under optimized conditions by Merrifield solid-phase methodology using the N alpha-Fmoc protecting group to authenticate the primary structure. Expand
Synthetic, structural and biological studies of the ubiquitin system: the total chemical synthesis of ubiquitin.
The small protein ubiquitin (76 amino acids) has been synthesized under optimized conditions by Merrifield solid-phase methodology using the N alpha-Fmoc protecting group. The crude polypeptideExpand
Fast and simultaneous determination of urinary 8-hydroxy-2'-deoxyguanosine and ten monohydroxylated polycyclic aromatic hydrocarbons by liquid chromatography/tandem mass spectrometry.
TLDR
A novel method to quickly and simultaneously quantify ten urinary OH-PAHs and 8-OHdG through high pressure liquid chromatography/tandem mass spectrometry (HPLC/MS/MS) shows satisfactory accuracy and precision when it analyzed varied levels spiked in pooled urine. Expand
Chemically synthesized ubiquitin extension proteins detect distinct catalytic capacities of deubiquitinating enzymes.
TLDR
Solid-phase chemistry is used to synthesize proteins equivalent to a human ubiquitin precursor and representative of isopeptide-linked Ubiquitin-protein conjugates, demonstrating that the synthetic approach offers an alternative to recombinant methods for the production of small proteins in vitro. Expand
Mapping the active site of endothelin-converting enzyme-1 through subsite specificity and mutagenesis studies: a comparison with neprilysin.
TLDR
Sub substrates based on the sequence of the COOH-terminal half of big endothelin-1 are used to examine the subsite specificity of recombinant ECE-1 and reveal that the S(1) pocket of ECE (ECE-1) is relatively nonselective, but that theS'( 1) subsite of E CE-1 has a preference for large hydrophobic side chains. Expand
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