Author pages are created from data sourced from our academic publisher partnerships and public sources.
- Publications
- Influence
Novel aminoglycosides increase SMN levels in spinal muscular atrophy fibroblasts
- Virginia B. Mattis, R. Rai, J. Wang, C. T. Chang, Tristan H. Coady, C. L. Lorson
- Biology, Medicine
- Human Genetics
- 2 September 2006
Spinal muscular atrophy (SMA) is the leading genetic cause of infant mortality. SMA is caused by the homozygous absence of survival motor neuron-1 (SMN1). SMN2, a nearly identical copy gene, is… Expand
Synthesis and Pharmacological Activity of a Potent Inhibitor of the Biosynthesis of the Endocannabinoid 2‐Arachidonoylglycerol
- T. Bisogno, James J. Burston, +6 authors Vincenzo Di Marzo
- Chemistry, Medicine
- ChemMedChem
- 8 June 2009
Biosynthesis Inhibition: O‐5596, a new inhibitor of the biosynthesis of the endocannabinoid, 2‐arachidonoylglycerol, was synthesized and found to be potent (IC50=100 nM) and selective versus other… Expand
Pyranmycins, a novel class of aminoglycosides with improved acid stability: the SAR of D-pyranoses on ring III of pyranmycin.
- C. Chang, Yu Hui, Bryan Elchert, J. Wang, J. Li, R. Rai
- Chemistry, Medicine
- Organic letters
- 21 November 2002
[reaction: see text] The synthesis of a novel class of aminoglycosides, pyranmycins, is reported along with the structure activity relationship (SAR) of their antibacterial activity against… Expand
Synthesis of trehalose-based compounds and their inhibitory activities against Mycobacterium smegmatis.
- J. Wang, Bryan Elchert, +6 authors C. Chang
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 15 December 2004
The synthesis of a library of trehalose-based compounds has been accomplished, and their activities against Mycobacterium smegmatis have been determined. A preliminary structure-activity relationship… Expand
Synthesis of novel aminoglycosides via allylic azide rearrangement for investigating the significance of 2'-amino group.
- J. Zhang, A. Litke, Katherine J. Keller, R. Rai, C. Chang
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 15 February 2010
Using allylic azide rearrangement, a convenient method has been developed for the synthesis of 2',3'-dideoxyaminoglycosides that are, otherwise, difficult to be prepared. The antibacterial activity… Expand
A Review on Intention Models for Predicting Entrepreneurial Behavior
Entrepreneurship development is viewed as the success mantra in the upliftment of social and economic backwardness. The development of the entrepreneurial mindset is assumed that an outcome of proper… Expand
- 7
- 1
Application of the synthetic aminosugars for glycodiversification: synthesis and antimicrobial studies of pyranmycin.
- Bryan Elchert, J. Li, +7 authors C. Chang
- Chemistry, Medicine
- The Journal of organic chemistry
- 28 January 2004
A divergent approach was employed for the synthesis of aminosugars, from which a novel library of aminoglycoside antibiotics (pyranmycins) was synthesized. Pyranmycins have comparable antibacterial… Expand
Investigation of antibacterial mode of action for traditional and amphiphilic aminoglycosides.
- Venkatareddy Udumula, Y. Ham, +5 authors C. Chang
- Chemistry, Medicine
- Bioorganic & medicinal chemistry letters
- 15 March 2013
Aminoglycoside represents a class of versatile and broad spectrum antibacterial agents. In an effort to revive the antibacterial activity against aminoglycoside resistant bacteria, our laboratory has… Expand
Novel Method for the Synthesis of 3′,4′‐Dideoxygenated Pyranmycin and Kanamycin Compounds, and Studies of Their Antibacterial Activity Against Aminoglycoside‐Resistant Bacteria
- R. Rai, Hsiao-Nung Chen, Huiwen Chang, Cheng‐Wei Tom Chang
- Chemistry
- 1 March 2005
A novel protocol for converting a trans‐diol to an alkene under mild conditions was developed. This method led to the synthesis of a 3′,4′‐dideoxykanamycin (dibekacin) analog and a… Expand