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Endothelial Outgrowth Cells Are Not Derived From CD133+ Cells or CD45+ Hematopoietic Precursors
Objective—Two types of endothelial progenitor cells (EPCs), early EPCs and late EPCs (also called endothelial outgrowth cells [EOCs]), were described in vitro previously. In this report, we dissectExpand
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Increased hippocampal noradrenaline is a biomarker for efficacy of vagus nerve stimulation in a limbic seizure model
J. Neurochem. (2011) 117, 461–469.
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Seizures in the intrahippocampal kainic acid epilepsy model: characterization using long‐term video‐EEG monitoring in the rat
Objective –  Intrahippocampal injection of kainic acid (KA) in rats evokes a status epilepticus (SE) and leads to spontaneous seizures. However to date, precise electroencephalographic (EEG) andExpand
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Suppression of hippocampal epileptic seizures in the kainate rat by Poisson distributed stimulation
Purpose:  Hippocampal deep brain stimulation (DBS) is an experimental therapy for patients with pharmacoresistant temporal lobe epilepsy (TLE). Despite the successful clinical application of DBS, theExpand
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Vagus nerve stimulation…25 years later! What do we know about the effects on cognition?
VNS therapy was delivered to patients for the first time in 1988. After 25 years, insight in the antiepileptic and antidepressant mechanism of action of VNS has grown steadily. The effects onExpand
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Levetiracetam: part II, the clinical profile of a novel anticonvulsant drug.
The objective of this article was to review and summarize the available reports on the profile of the novel anticonvulsant drug levetiracetam (LEV) in a clinical setting. Therefore, a careful searchExpand
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A Decade of Experience with Deep Brain Stimulation for patients with Refractory Medial Temporal Lobe epilepsy
We present long-term results from patients with medial temporal lobe (MTL) epilepsy treated with deep brain stimulation (DBS). Expand
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Ictal‐onset localization through connectivity analysis of intracranial EEG signals in patients with refractory epilepsy
Fifteen percent to 25% of patients with refractory epilepsy require invasive video–electroencephalography (EEG) monitoring (IVEM) to precisely delineate the ictal‐onset zone. This delineation basedExpand
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Antiepileptic drugs modulate P-glycoproteins in the brain: A mice study with 11C-desmethylloperamide
P-glycoprotein transporters (P-gp) located at the blood-brain barrier (BBB) are likely to play a role in refractory epilepsy. In vitro studies already pointed out that several antiepileptic drugsExpand
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Chronic levetiracetam treatment early in life decreases epileptiform events in young GAERS, but does not prevent the expression of spike and wave discharges during adulthood
PURPOSE In Genetic Absence Epilepsy Rats from Strasbourg (GAERS), age-related absence seizures start to appear from postnatal day (PN) 30 concomitant with 'spike and wave discharges' (SWDs) appearingExpand
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