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HIV-1 Tat protein mimicry of chemokines.
The HIV-1 Tat protein is a potent chemoattractant for monocytes. We observed that Tat shows conserved amino acids corresponding to critical sequences of the chemokines, a family of molecules knownExpand
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Human Mig chemokine: biochemical and functional characterization
Mig is a chemokine of the CXC subfamily that was discovered by differential screening of a cDNA library prepared from lymphokine- activated macrophages. The mig gene is inducible in macrophages andExpand
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Chemokine receptor responses on T cells are achieved through regulation of both receptor expression and signaling.
To address the issues of redundancy and specificity of chemokines and their receptors in lymphocyte biology, we investigated the expression of CC chemokine receptors CCR1, CCR2, CCR3, CCR5, CXCR3,Expand
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Suppression of the Induction of Alpha, Beta, and Lambda Interferons by the NS1 and NS2 Proteins of Human Respiratory Syncytial Virus in Human Epithelial Cells and Macrophages
Wild-type human respiratory syncytial virus (HRSV) is a poor inducer of alpha/beta interferons (IFN-alpha/beta). However, recombinant HRSV lacking the NS1 and NS2 genes (Delta NS1/2) induced highExpand
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Suppression of the Induction of Alpha, Beta, and Gamma Interferons by the NS1 and NS2 Proteins of Human Respiratory Syncytial Virus in Human Epithelial Cells and Macrophages
ABSTRACT Wild-type human respiratory syncytial virus (HRSV) is a poor inducer of alpha/beta interferons (IFN-α/β). However, recombinant HRSV lacking the NS1 and NS2 genes (ΔNS1/2) induced high levelsExpand
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Mycobacterium tuberculosis Triggers Host Type I IFN Signaling To Regulate IL-1β Production in Human Macrophages
Mycobacterium tuberculosis is a virulent intracellular pathogen that survives in macrophages even in the presence of an intact adaptive immune response. Type I IFNs have been shown to exacerbateExpand
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Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptor
Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) enter target cells by forming a complex between the viral envelope protein and two cell-surface membrane receptors: CD4 andExpand
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CC-Chemokine Receptor 6 Is Expressed on Diverse Memory Subsets of T Cells and Determines Responsiveness to Macrophage Inflammatory Protein 3α
CC-chemokine receptor (CCR) 6 is the only known receptor for macrophage inflammatory protein (MIP)-3α, a CC chemokine chemotactic for lymphocytes and dendritic cells. Using anti-serum that we raisedExpand
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CC-chemokine receptor 6 is expressed on diverse memory subsets of T cells and determines responsiveness to macrophage inflammatory protein 3 alpha.
CC-chemokine receptor (CCR) 6 is the only known receptor for macrophage inflammatory protein (MIP)-3alpha, a CC chemokine chemotactic for lymphocytes and dendritic cells. Using anti-serum that weExpand
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Human B Cells Become Highly Responsive to Macrophage-Inflammatory Protein-3α/CC Chemokine Ligand-20 After Cellular Activation Without Changes in CCR6 Expression or Ligand Binding
CCR6 is the only known receptor for the chemokine macrophage-inflammatory protein (MIP)-3α/CC chemokine ligand (CCL)20. We have shown previously that CCR6 is expressed on peripheral blood B cells,Expand
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