• Publications
  • Influence
Escherichia coli secretion of an active chimeric antibody fragment.
TLDR
The production in Escherichia coli of foreign heterodimeric protein reagents, such as Fab, should prove useful in the management of human disease. Expand
Secretion of functional antibody and Fab fragment from yeast cells.
TLDR
Yeast strains that secrete functional mouse-human chimeric antibody and its Fab fragment into the culture medium are constructed and chimeric whole antibody exhibited antibody-dependent cellular cytot toxicity activity but not complement-dependent cytotoxicity activity. Expand
Expression of mouse::human immunoglobulin heavy-chain cDNA in lymphoid cells.
TLDR
A chimeric mouse variable::human constant immunoglobulin heavy-chain gene was expressed in transfected mouse Sp2/0 cells and an adventitious oligo(C) sequence, introduced by the method of gene construction at a site located 8 nt residues downstream from a splICE acceptor, can apparently direct splicing towards a cryptic splice acceptor downstream from the oligo (C). Expand
Chimeric mouse-human IgG1 antibody that can mediate lysis of cancer cells.
TLDR
The chimeric antibody, but not the mouse L6 antibody, is effective against a melanoma line expressing small amounts of the L6 antigen, and points to the usefulness of the chimeric antibodies approach for obtaining agents with strong antitumor activity for possible therapeutic use in man. Expand
Production of a mouse-human chimeric monoclonal antibody to CD20 with potent Fc-dependent biologic activity.
TLDR
A chimeric 2H7 antibody is generated by substituting the mouse constant domains of 2H6 with the human gamma 1 and kappa domains and is highly effective in mediating antibody-dependent cellular cytotoxicity with human effector cells and complement-dependent cytot toxicity with human complement. Expand
Augmentation of antibody dependent cell mediated cytotoxicity following in vivo therapy with recombinant interleukin 2.
TLDR
Combining IL-2 with mAB in clinical tumor therapy may lead to a wider range of tumor types being responsive to immunotherapy and may also enhance the efficacy of therapy by specifically targeting activated effector cells to tumor cells recognized by mAB. Expand
Binding and functional properties of a mouse-human chimeric monoclonal antibody of the human IgG1 subclass with specificity for human carcinomas.
TLDR
The in vitro activation of cell-dependent cytolysis observed with the chimeric antibodies when effector cells from both normal and tumor-bearing donors were used strongly suggests that comparable activity would be observed in vivo. Expand
Daclizumab, an IL-2 modulating antibody for treatment of multiple sclerosis
TLDR
In recently completed randomized trials in RRMS, treatment with daclizumab monotherapy compared with placebo resulted in clinically meaningful and statistically significant reductions in relapses, active lesions on brain MRI and slowing of disability progression. Expand
Analysis of a Drosophila tRNA gene cluster: Two tRNALeu genes contain intervening sequences
TLDR
A recombinant DNA phage containing a cluster of Drosophila melanogaster t RNA genes has been isolated and analyzed and two tRNA genes are assigned to be tRNALeu genes because of significant sequence homology with yeast tRNA3Leu, and secondary structure homology in the intervening sequences of yeast t RNALeu intervening sequence. Expand
Multiple mRNA species with distinct 3′ termini are transcribed from the β2-microglobulin gene
TLDR
It is demonstrated that the single β2-microglobulin gene is transcribed into at least two different size classes of mRNA that differ in the lengths of their 3′ untranslated regions. Expand
...
1
2
3
...