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The single-stranded DNA-binding protein of Escherichia coli.
The single-stranded DNA-binding protein (SSB) of Escherichia coli is involved in all aspects of DNA metabolism: replication, repair, and recombination. In solution, the protein exists as aExpand
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Deoxyribonucleic acid biosynthesis in mitochondria. Purification and general properties of rat liver mitochondrial deoxyribonucleic acid polymerase.
Abstract Deoxyribonucleic acid polymerase has been purified 3550-fold from rat liver mitochondria, which computes to 14,000-fold based on whole liver as the starting material. The enzyme isExpand
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Mutant single-strand binding protein of Escherichia coli: genetic and physiological characterization.
A mutation in the Escherichia coli gene for single-strand binding protein results in temperature-sensitive deoxyribonucleic acid replication (R. R. Meyer, J. Glassberg, and A. Kornberg, Proc. Natl.Expand
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An Escherichia coli mutant defective in single-strand binding protein is defective in DNA replication.
An Escherichia coli mutant, temperature-sensitive for DNA synthesis in vivo and in vitro, is defective in single-strand binding protein (SSB; DNA-binding protein). Conversion of phage G4 singleExpand
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Mammalian DNA polymerases alpha, beta, gamma, delta, and epsilon incorporate fialuridine (FIAU) monophosphate into DNA and are inhibited competitively by FIAU Triphosphate.
Fialuridine [FIAU, 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5- iodouridine] was used in clinical trials for chronic hepatitis B virus infection and was extremely toxic. Evidence suggestedExpand
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Influence of single-stranded DNA-binding protein on recA induction in Escherichia coli.
Two ssb mutants of Escherichia coli, which carry a lesion in the single-strand DNA-binding protein (SSB), are sensitive to UV-irradiation. We have investigated the influence of SSB on the "SOS"Expand
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Variability in the nucleic acid binding site size and the amount of single‐stranded DNA‐binding protein in Escherichia coli
The Escherichia coli single‐stranded DNA binding protein (SSB), essential for DNA replication, recombination and repair, can undergo a thermally induced irreversible conformational change which doesExpand
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The product of the lexC gene of Escherichia coli is single-stranded DNA-binding protein.
Extracts from lexC113 cells could not support phage G4 DNA-dependent replication unless supplemented with single-stranded DNA-binding protein. Purified lexC113 binding protein supported synthesis inExpand
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Interaction of a folded chromosome-associated protein with single-stranded DNA-binding protein of Escherichia coli, identified by affinity chromatography.
A single-stranded DNA-binding protein (SSB) affinity column was prepared by optimizing the coupling of Escherichia coli single-stranded DNA-binding protein to Affi-Gel 10. The bound SSB retained itsExpand
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DNA biosynthesis in mitochondria. Differential inhibition of mitochondrial and nuclear DNA polymerases by the mutagenic dyes ethidium bromide and acriflavin.
Abstract The DNA-intercalating dyes ethidium bromide and acriflavin strongly inhibit the enzymatic synthesis of DNA catalyzed by rat liver mitochondrial DNA polymerase. When compared with the nuclearExpand
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