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Maternal obesity and markers of inflammation in pregnancy.
OBJECTIVES To evaluate whether obesity is associated with changes in pro-inflammatory and immunomodulatory cytokines in pregnancy. METHODS We performed a cross-sectional study using maternal serumExpand
Gastric bypass model in the obese rat to study metabolic mechanisms of weight loss.
A rat model replicating gastric bypass with Roux-en-Y (GB) as used in morbidly obese patients, evolved in our laboratory in stages, using the Zucker rat as an obese model (GB) is presented. In theExpand
Is obesity an inflammatory disease?
BACKGROUND Most obese individuals have elevated concentrations of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha), markers of inflammation closely associated with diabetes,Expand
A surgical rat model of human Roux-en-Y gastric bypass
Obesity affects 30% of the United States population and its detrimental effects are obesity-related metabolic diseases. For patients refractory to conventional weight loss therapy, gastric bypassExpand
Gene expression profiles post Roux-en-Y gastric bypass.
BACKGROUND The hypothalamus is involved in regulation of food intake (FI) and fat deposition. Molecular mechanisms of weight loss after Roux-en-Y gastric bypass (RYGB) were studied by correlatingExpand
Neurobiologic changes in the hypothalamus associated with weight loss after gastric bypass.
BACKGROUND Effects of Roux-en-Y gastric bypass (RYGB) on hypothalamic food intake regulation have not been investigated. The hypothalamic arcuate nucleus (ARC) and the magnocellular (m) andExpand
Infertility in mice infected genitally with a human strain of Chlamydia trachomatis.
Progesterone-treated C3H and TO mice were inoculated genitally with a human C. trachomatis strain, serovar E, designated N.I. 1 or with 2SP control medium. Of the C3H mice serving as controls 93% hadExpand
Feeding behavior during sialodacryoadenitis viral infection in rats
Abstract Sialodacryoadenitis (SDA) is a highly contagious common viral infection in rats, akin to mumps in humans. Anorexia occurs during such viral infection. But the pattern of the decrease inExpand