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- Publications
- Influence
The re-emergence of natural products for drug discovery in the genomics era
- A. Harvey, Ruangelie Edrada-Ebel, R. Quinn
- Biology, Medicine
- Nature Reviews Drug Discovery
- 23 January 2015
Natural products have been a rich source of compounds for drug discovery. However, their use has diminished in the past two decades, in part because of technical barriers to screening natural… Expand
Biodiversity ‘hotspots’, patterns of richness and endemism, and taxonomic affinities of tropical Australian sponges (Porifera)
- J. Hooper, J. Kennedy, R. Quinn
- Biology
- Biodiversity & Conservation
- 1 May 2002
Abstract‘Hotspots’ of biodiversity (taxonomic richness, endemism, taxonomic affinities between communities) at small (α), medium (β) and larger (γ) scales of diversity were examined for marine sponge… Expand
Developing a drug-like natural product library.
- R. Quinn, A. Carroll, +5 authors S. Muresan
- Engineering, Medicine
- Journal of natural products
- 8 February 2008
Addressing drug-like/lead-like properties of biologically active small molecules early in a lead generation program is the current paradigm within the drug discovery community. Lipinski's "rule of… Expand
Adenosine receptors: new opportunities for future drugs.
- S. Poulsen, R. Quinn
- Biology, Medicine
- Bioorganic & medicinal chemistry
- 1 June 1998
This review summarises current knowledge on adenosine receptors, an important G protein-coupled receptor. The four known adenosine receptor subtypes A1, A2A, A2B, and A3 are discussed with special… Expand
Phospholipase A2 in cnidaria.
- T. Nevalainen, H. Peuravuori, +4 authors K. Winkel
- Biology, Medicine
- Comparative biochemistry and physiology. Part B…
- 1 December 2004
Phospholipase A2 (PLA2) is an enzyme present in snake and other venoms and body fluids. We measured PLA2 catalytic activity in tissue homogenates of 22 species representing the classes Anthozoa,… Expand
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond
- W. V. Van Voorhis, J. Adams, +184 authors P. Willis
- Biology, Medicine
- PLoS pathogens
- 1 July 2016
A major cause of the paucity of new starting points for drug discovery is the lack of interaction between academia and industry. Much of the global resource in biology is present in universities,… Expand
Elicitation of secondary metabolism in actinomycetes.
- U. R. Abdelmohsen, T. Grkovic, Srikkanth Balasubramanian, M. S. Kamel, R. Quinn, U. Hentschel
- Biology, Medicine
- Biotechnology advances
- 1 November 2015
Genomic sequence data have revealed the presence of a large fraction of putatively silent biosynthetic gene clusters in the genomes of actinomycetes that encode for secondary metabolites, which are… Expand
The fatty acid synthase inhibitor triclosan: repurposing an anti-microbial agent for targeting prostate cancer
- Martin C. Sadowski, Rebecca H. Pouwer, J. Gunter, A. Lubik, R. Quinn, C. Nelson
- Biology, Medicine
- Oncotarget
- 3 September 2014
Inhibition of FASN has emerged as a promising therapeutic target in cancer, and numerous inhibitors have been investigated. However, severe pharmacological limitations have challenged their clinical… Expand
Antimalarial bromotyrosine derivatives from the Australian marine sponge Hyattella sp.
- Xinzhou Yang, R. Davis, +4 authors R. Quinn
- Biology, Medicine
- Journal of natural products
- 12 May 2010
A drug discovery program aimed at identifying new antimalarial leads from a prefractionated natural product library has resulted in the identification of a new bromotyrosine alkaloid, psammaplysin G… Expand
Natural products as lead structures: chemical transformations to create lead-like libraries.
- Mauro Pascolutti, R. Quinn
- Chemistry, Medicine
- Drug discovery today
- 1 March 2014
In this review, we analyze and illustrate the variation of the two main lead-like descriptors [molecular weight (MW) and the partition coefficient (logP)] in the generation of libraries in which a… Expand