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The re-emergence of natural products for drug discovery in the genomics era
This work reviews strategies for natural product screening that harness the recent technical advances that have reduced technical barriers and assess the use of genomic and metabolomic approaches to augment traditional methods of studying natural products.
Biodiversity ‘hotspots’, patterns of richness and endemism, and taxonomic affinities of tropical Australian sponges (Porifera)
Sponge faunas at the α and γ scales of diversity are ineffective and inappropriate as biodiversity models, respectively, with γ scale diversity also less relevant as a practical tool for marine resource management and marine area conservation.
Developing a drug-like natural product library.
A natural product library (NPL) is generated in which 85% of the isolated compounds had no Lipinski violations and demonstrates the feasibility of obtaining natural products known for rich chemical diversity with the required physicochemical properties for drug discovery.
Adenosine receptors: new opportunities for future drugs.
This review summarises current knowledge on adenosine receptors, an important G protein-coupled receptor, with special reference to the opportunities for drug development.
Phospholipase A2 in cnidaria.
The current observations support the idea that cnidarian PLA2 may participate in the sting site irritation and systemic envenomation syndrome resulting from contact with cNidarians.
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond
The results reveal the immense potential for translating the dispersed expertise in biological assays involving human pathogens into drug discovery starting points, by providing open access to new families of molecules, and emphasize how a small additional investment made to help acquire and distribute compounds, and sharing the data, can catalyze drug discovery for dozens of different indications.
Psammaplysin H, a new antimalarial bromotyrosine alkaloid from a marine sponge of the genus Pseudoceratina.
A new antimalarial bromotyrosine alkaloid is purified along with the previously isolated analogs psammaplysins G (2) and F (3) and the structure of 1 was elucidated following 1D and 2D NMR, and MS data analysis.
Antimalarial activity of pyrroloiminoquinones from the Australian marine sponge Zyzzya sp.
A new bispyrroloiminoquinone alkaloid, tsitsikammamine C (1), displayed potent in vitro antimalarial activity with IC(50) values of 13 and 18 nM against chloroquine-sensitive (3D7) and
Elicitation of secondary metabolism in actinomycetes.
This review focuses on the effects of biological, chemical, as well as molecular elicitation on secondary metabolism in actinomycetes and exemplifies the diversity of natural products that have been recovered by such approaches from the phylum Actinobacteria.
Natural products as lead structures: chemical transformations to create lead-like libraries.
From this analysis, a schematic approach to the generation of lead-like libraries that can be applied to any starting NP is presented.