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The re-emergence of natural products for drug discovery in the genomics era
Natural products have been a rich source of compounds for drug discovery. However, their use has diminished in the past two decades, in part because of technical barriers to screening naturalExpand
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Biodiversity ‘hotspots’, patterns of richness and endemism, and taxonomic affinities of tropical Australian sponges (Porifera)
Abstract‘Hotspots’ of biodiversity (taxonomic richness, endemism, taxonomic affinities between communities) at small (α), medium (β) and larger (γ) scales of diversity were examined for marine spongeExpand
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Developing a drug-like natural product library.
Addressing drug-like/lead-like properties of biologically active small molecules early in a lead generation program is the current paradigm within the drug discovery community. Lipinski's "rule ofExpand
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Adenosine receptors: new opportunities for future drugs.
This review summarises current knowledge on adenosine receptors, an important G protein-coupled receptor. The four known adenosine receptor subtypes A1, A2A, A2B, and A3 are discussed with specialExpand
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Phospholipase A2 in cnidaria.
Phospholipase A2 (PLA2) is an enzyme present in snake and other venoms and body fluids. We measured PLA2 catalytic activity in tissue homogenates of 22 species representing the classes Anthozoa,Expand
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Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond
A major cause of the paucity of new starting points for drug discovery is the lack of interaction between academia and industry. Much of the global resource in biology is present in universities,Expand
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Elicitation of secondary metabolism in actinomycetes.
Genomic sequence data have revealed the presence of a large fraction of putatively silent biosynthetic gene clusters in the genomes of actinomycetes that encode for secondary metabolites, which areExpand
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The fatty acid synthase inhibitor triclosan: repurposing an anti-microbial agent for targeting prostate cancer
Inhibition of FASN has emerged as a promising therapeutic target in cancer, and numerous inhibitors have been investigated. However, severe pharmacological limitations have challenged their clinicalExpand
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Antimalarial bromotyrosine derivatives from the Australian marine sponge Hyattella sp.
A drug discovery program aimed at identifying new antimalarial leads from a prefractionated natural product library has resulted in the identification of a new bromotyrosine alkaloid, psammaplysin GExpand
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Natural products as lead structures: chemical transformations to create lead-like libraries.
In this review, we analyze and illustrate the variation of the two main lead-like descriptors [molecular weight (MW) and the partition coefficient (logP)] in the generation of libraries in which aExpand
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