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PCAF-dependent epigenetic changes promote axonal regeneration in the central nervous system.
Axonal regenerative failure is a major cause of neurological impairment following central nervous system (CNS) but not peripheral nervous system (PNS) injury. Notably, PNS injury triggers aExpand
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HDAC inhibition promotes neuronal outgrowth and counteracts growth cone collapse through CBP/p300 and P/CAF-dependent p53 acetylation
Neuronal outgrowth is guided by both extrinsic and intrinsic factors, involving transcriptional regulation. The acetylation of histones and transcription factors, which facilitates promoterExpand
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A p53-CBP/p300 transcription module is required for GAP-43 expression, axon outgrowth, and regeneration
Transcription regulates axon outgrowth and regeneration. However, to date, no transcription complexes have been shown to control axon outgrowth and regeneration by regulating axon growth genes. Here,Expand
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The MDM4/MDM2-p53-IGF1 axis controls axonal regeneration, sprouting and functional recovery after CNS injury.
Regeneration of injured central nervous system axons is highly restricted, causing neurological impairment. To date, although the lack of intrinsic regenerative potential is well described, a keyExpand
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PP4-dependent HDAC3 dephosphorylation discriminates between axonal regeneration and regenerative failure
The molecular mechanisms discriminating between regenerative failure and success remain elusive. While a regeneration-competent peripheral nerve injury mounts a regenerative gene expression responseExpand
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RA–RAR-β counteracts myelin-dependent inhibition of neurite outgrowth via Lingo-1 repression
Central nervous system injury results in the release of molecules that inhibit neuronal regeneration, but retinoic acid counteracts this effect by inhibiting Lingo-1.
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Epigenetic Regulation of Axon Outgrowth and Regeneration in CNS Injury: The First Steps Forward
Inadequate axonal sprouting and lack of regeneration limit functional recovery following neurologic injury, such as stroke, brain, and traumatic spinal cord injury. Recently, the enhancement of theExpand
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Biomaterial-Supported Cell Transplantation Treatments for Spinal Cord Injury: Challenges and Perspectives
Spinal cord injury (SCI), resulting in para- and tetraplegia caused by the partial or complete disruption of descending motor and ascending sensory neurons, represents a complex neurologicalExpand
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Retinoic acid signaling in axonal regeneration
Following an acute central nervous system (CNS) injury, axonal regeneration and functional recovery are extremely limited. This is due to an extrinsic inhibitory growth environment and the lack ofExpand
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Regulation of Adult CNS Axonal Regeneration by the Post-transcriptional Regulator Cpeb1
Adult mammalian central nervous system (CNS) neurons are unable to regenerate following axonal injury, leading to permanent functional impairments. Yet, the reasons underlying this regenerationExpand