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Acidic pH-Induced Conformations and LAMP1 Binding of the Lassa Virus Glycoprotein Spike
TLDR
Three-dimensional ultrastructure of Lassa virus using electron cryotomography shows a viral entry mechanism dependent on binding to the lysosome-resident receptor LAMP1 and further dissociation of the membrane-distal GP1 subunits is supported.
Fibrillar islet amyloid polypeptide (amylin) is internalised by macrophages but resists proteolytic degradation
TLDR
Fibrils can be phagocytosed by macrophages in vitro but amyloid-associated factors may block the recognition of fibrils in vivo preventing the removal of islet ameloid in diabetes.
A key region of molecular specificity orchestrates unique ephrin-B1 utilization by Cedar virus
TLDR
The structural and functional insights presented uncover diversity within the known henipavirus receptor repertoire and suggest that only modest structural changes may be required to modulate receptor specificities within this group of lethal human pathogens.
A key region of molecular specificity orchestrates unique ephrin-B1 utilization by Cedar virus
TLDR
CedV possesses a unique cellular entry receptor repertoire which, in addition to functional utilization of the common HNV receptor, includes the hitherto uncharacterized interaction with ephrin-B1, andCrystal structures reveal a conserved recognition mode between diverse HNV-G proteins and their distinct Ephrin receptors and identify a region of molecular specificity within CedV-G that is a key determinant of ephrine selectivity.
Molecular Evolution, Diversity, and Adaptation of Influenza A(H7N9) Viruses in China
TLDR
Investigating the evolution and adaptation of H7N9 viruses by analyzing available data and newly generated virus sequences isolated in Guangdong Province, China, during 2015–2017 indicates that highly pathogenic strains likely emerged from viruses circulating in eastern Guangdongs Province and are associated with a high rate of adaptive molecular evolution.
A structural basis for antibody-mediated neutralization of Nipah virus reveals a site of vulnerability at the fusion glycoprotein apex
TLDR
The membrane-distal regions of NiV-F and the F glycoprotein from closely related Hendra virus are revealed as attractive targets for antiviral and vaccine development and are targeted by the antibody-mediated immune response across henipaviruses.
Structure-Based Classification Defines the Discrete Conformational Classes Adopted by the Arenaviral GP1
TLDR
Comparisons of the GP1 glycoprotein architectures of Old World Loei River virus and New World Whitewater Arroyo virus show that these rearrangements are restricted to Old World arenaviruses and are not induced solely by the pH change that is associated with virus endosomal trafficking.
Prolonged Infectious SARS-CoV-2 Shedding from an Immunocompromised Patient
TLDR
The data indicate that certain immunocompromised patients may shed infectious virus for longer durations than previously recognized, and detection of of subgenomic RNA is recommended in persistently SARS-CoV-2 positive individuals as a proxy for shedding of infectious virus.
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