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The Dynamic Process of β2-Adrenergic Receptor Activation
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Structural Insights into the Dynamic Process of β2-Adrenergic Receptor Signaling
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Ligand-specific regulation of the extracellular surface of a G protein coupled receptor
TLDR
NMR spectroscopy is used to demonstrate conformational coupling between the ECS and the orthosteric binding site, showing that drugs targeting this diverse surface could function as allosteric modulators with high subtype selectivity.
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Bicelles: a model membrane system for all seasons?
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Activation of the A2A adenosine G-protein-coupled receptor by conformational selection
TLDR
Direct observation of the conformational equilibria of ligand-dependent G-protein-coupled receptor and deduction of the underlying mechanisms of receptor activation will have wide-reaching implications for the understanding of the function of G- proteins in health and disease.
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Magnetically Oriented Phospholipid Bilayered Micelles for Structural Studies of Polypeptides. Does the Ideal Bicelle Exist
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The role of ligands on the equilibria between functional states of a G protein-coupled receptor.
TLDR
Ligands greatly influence the overall changes in enthalpy and entropy of the system and the corresponding changes in population and amplitude of motion of given states, suggesting a complex landscape of states and substates.
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Isotropic solutions of phospholipid bicelles: A new membrane mimetic for high-resolution NMR studies of polypeptides
TLDR
The bicellar solutions still require in-depth morphological characterization, but they appear to be ideal media for NMRdetermination of the mode of binding and the structure of membrane-associated peptides andproteins.
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Structural Insights into the Dynamic Process of β2-Adrenergic Receptor Signaling
View on Elsevier
Current applications of bicelles in NMR studies of membrane-associated amphiphiles and proteins.
This review covers current trends in studies of membrane amphiphiles and membrane proteins using both fast tumbling bicelles and magnetically aligned bicelle media for both solution state and solid…
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