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Carcinogenic N-nitrosamines in the diet: occurrence, formation, mechanisms and carcinogenic potential.
Data suggest that humans are susceptible to carcinogenesis by N-nitroso compounds and that the presence of these compounds in some foods may be regarded as an aetiological risk factor for certain human cancers including cancers of the oesophagus, stomach and nasopharynx. Expand
Influence of dietary nitrate on nitrite content of human saliva: possible relevance to in vivo formation of N-nitroso compounds.
There is a direct relationship between the salivary nitrite concentrations and the amounts of nitrate ingested in the diet, and the possible relevance of these findings to the endogenous formation of N-nitroso compounds in the gastro-intestinal tract is discussed. Expand
N-nitroso compounds in cigarette tobacco and their occurrence in mainstream tobacco smoke.
The tobacco and mainstream smoke of 20 commercial brands of filter and non-filter cigarettes were analysed for N-nitroso compounds and the concentrations of N- nitrogen compounds in cigarette tobacco were very much lower than in mainstream smoke. Expand
Occurrence and exposure to N-nitroso compounds and precursors.
Teratogenic and Carcinogenic Effects in the Offspring after Single Injection of Ethylnitrosourea to Pregnant Rats
M mothylnitrosourea is a potent carcinogens, also mutagenic as in Saccharomyces cerevisiae and is teratogenic in rats, and in teratogenesis investigations the embryos are generally killed and examined immediately after Caesarean delivery. Expand
Occupational nitrosamine exposure. 1. Rubber and tyre industry.
Elimination of one or both precursors for nitrosamine formation resulted in significant reduction of airial contamination of nitrosamines, as basis for future epidemiological studies and their potential for exposure prevention. Expand
Mean daily intake of volatile N-nitrosamines from foods and beverages in West Germany in 1989-1990.
The levels of volatile N-nitrosamines were determined in 38 alcoholic drinks and 215 food samples prepared for human consumption using standard culinary practices and found that 31% of the daily NDMA exposure results from the consumption of beer. Expand
N-nitrosamines in the saliva of tobacco chewers or masheri users.
Saliva was collected from men and women who were habitual chewers of tobacco (with lime or betel quid) and from women who used masheri. The saliva was analysed for tobacco-specific nitrosaminesExpand
Preformed tobacco-specific nitrosamines in tobacco--role of nitrate and influence of tobacco type.
The results demonstrated that there is a correlation between TSNA and nitrate levels, and the tobacco type is another important influencing factor, especially for NNK, while in Virginia tobaccos unexpectedly high NNK values were observed. Expand