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Rab11‐FIP3 and FIP4 interact with Arf6 and the Exocyst to control membrane traffic in cytokinesis
TLDR
It is proposed that FIP3 and FIP4 serve to couple Rab11‐positive vesicle traffic from recycling endosomes to the cleavage furrow/midbody where they are tethered prior to fusion events via interactions with Arf6 and the Exocyst.
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Ciliary targeting motif VxPx directs assembly of a trafficking module through Arf4
TLDR
It is shown that the newly identified ciliary targeting VxPx motif present in rhodopsin binds the small GTPase Arf4 and regulates its association with the trans‐Golgi network (TGN), which is the site of assembly and function of a ciliarytargeting complex.
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The FIP3-Rab11 protein complex regulates recycling endosome targeting to the cleavage furrow during late cytokinesis.
TLDR
It is proposed that the dynamic Rab11-FIP3 interaction controls the delivery, targeting, and fusion of recycling endosomes with furrow during late cytokinesis and abscission.
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Seven Novel Mammalian SNARE Proteins Localize to Distinct Membrane Compartments*
TLDR
Seven new mammalian proteins of the VAMP and syntaxin families are characterized, supporting the hypothesis that evolutionary radiation of these two gene families gave rise to sets of proteins whose differential expression and combinatorial associations define and organize the membrane compartments of cells.
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Syntaxin 13 Mediates Cycling of Plasma Membrane Proteins via Tubulovesicular Recycling Endosomes
TLDR
A role for syntaxin 13 in membrane fusion events during the recycling of plasma membrane proteins is supported by immunoprecipitation and confocal immunofluorescence results.
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Vamp-7 Mediates Vesicular Transport from Endosomes to Lysosomes
TLDR
A series of monoclonal and polyclonal antibodies against the cytoplasmic domain of vesicle-associated membrane protein 7 (VAMP-7) are generated, consistent with a role for VAMP- 7 in the vesicular transport of proteins from the early endosome to the lysosome.
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A Rab11/Rip11 protein complex regulates apical membrane trafficking via recycling endosomes.
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Arfophilins are dual Arf/Rab 11 binding proteins that regulate recycling endosome distribution and are related to Drosophila nuclear fallout.
TLDR
It is suggested that the novel dual GTPase-binding capacity of the arfophilins could serve as an interface of signals from Rab and Arf GTPases to regulate membrane traffic and integrate distinct signals in the late endosomal recycling compartment.
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Identification and localization of an actin-binding motif that is unique to the epsilon isoform of protein kinase C and participates in the regulation of synaptic function
TLDR
It is demonstrated that filamentous actin is a principal anchoring protein for PKC epsilon within intact nerve endings and indicates that actin filaments represent a new class of PKC- binding protein.
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Brain Myosin V Is a Synaptic Vesicle-associated Motor Protein: Evidence for a Ca2+-dependent Interaction with the Synaptobrevin–Synaptophysin Complex
TLDR
It is concluded that hydrophilic forces reversibly couple the myosin V tail to a biochemically defined class of organelles in brain nerve terminals in the absence of Mg2+.
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