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A simple clinical colitis activity index
The newly devised Simple Clinical Colitis Activity Index, consisting of scores for five clinical criteria, showed a highly significant correlation with the Powell-Tuck Index and could be useful in the initial assessment of patients with ulcerative colitis. Expand
PATHOGENESIS OF CROHN'S DISEASE: MULTIFOCAL GASTROINTESTINAL INFARCTION
The findings suggest that Crohn's disease is mediated by multifocal gastrointestinal infarction, and this pathogenetic process is compatible with many of the clinical features of Crohn't disease, and its recognition has important implications for the identification of the primary cause of the illness and advances in clinical management. Expand
Detection of herpesvirus DNA in the large intestine of patients with ulcerative colitis and Crohn's disease using the nested polymerase chain reaction
- A. Wakefield, J. Fox, +7 authors R. Pounder
- Biology, Medicine
- Journal of medical virology
- 1 November 1992
The high prevalence of coexistent HHV6 infection with either or both of these two viruses in ulcerative colitis tissue suggests that they may play a synergistic role in the pathogenesis of this disease. Expand
Intragastric bacterial activity and nitrosation before, during, and after treatment with omeprazole.
Short term treatment of healthy volunteers with omeprazole is associated with a short lived increase in the gastric bacterial flora, with endogenous production of N-nitroso compounds. Expand
Inappropriate hypergastrinaemia in asymptomatic healthy subjects infected with Helicobacter pylori.
Longterm hypergastrinaemia, associated with persistent H pylori infection, could be a cause of the increased parietal cell mass that is considered characteristic of duodenal ulcer patients. Expand
A randomized placebo-controlled trial of a humanized monoclonal antibody to alpha4 integrin in active Crohn's disease.
A single 3-mg/kg natalizumab infusion was well tolerated by Crohn's disease patients, although the dose used may have been suboptimal, and elevated circulating lymphocyte levels after natalIZumab suggest interrupted lymphocyte trafficking. Expand
Prevalence of gastrointestinal diseases in two British national birth cohorts
An increasing temporal trend in the prevalence of CD is indicated and a period effect in IBS is suggested, possibly due to adult life exposures or variation in recognition and diagnosis of IBS. Expand
A survey of dyspepsia in Great Britain
The clinical features, treatment, effect of dyspepsia on daily lives and perceptions of peptic ulcer disease are described and the cross‐sectional survey of the adult population using structured questionnaires is used. Expand
Inherited disorders of coagulation appear to protect against inflammatory bowel disease.
This epidemiological study provides further evidence that thrombosis and vascular occlusion may be important in the pathogenesis of inflammatory bowel disease. Expand
Crohn's disease: pathogenesis and persistent measles virus infection.
Crohn's disease may be a chronic granulomatous vasculitis in reaction to a persistent infection with measles virus within the vascular endothelium, according to preliminary evidence from both epidemiological and basic scientific data. Expand