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The prevalence of Helicobacter pylori infection in different countries.
The prevalence of Helicobacter pylori infection in a community is related to three factors: firstly, the rate of acquisition of infection with H. pylori--that is, incidence; secondly, the rate ofExpand
Clostridium difficile and inflammatory bowel disease.
Stools from 109 patients with inflammatory bowel disease (13.4%) contained Clostridium difficile or its toxin, an incidence similar to the stools of 99 control patients with diarrhoea (11.9%), butExpand
Evidence of persistent measles virus infection in Crohn's disease
The observations suggest that measles virus is capable of causing persistent infection of the intestine and that Crohn's disease may be caused by a granulomatous vasculitis in response to this virus. Expand
Evaluation of the polymerase chain reaction for detecting the urease C gene of Helicobacter pylori in gastric biopsy samples and dental plaque.
Results showed that primer pair sequences within the urease C gene are conserved in most strains and provide an accurate basis for detecting H. pylori in dental plaque. Expand
Mucosal capillary thrombi in rectal biopsies
Thrombi were observed in 8/13 cases of ulcerative colitis, 4/10 cases of Crohn's disease, 1/3 cases of unspecified inflammatory bowel disease and 5/20 cases of self‐limited colitis; the presence of capillary thrombi was not related to the severity of inflammation, but none of the control biopsies showed capillary Thrombi. Expand
Macrophage heterogeneity in normal colonic mucosa and in inflammatory bowel disease.
There was much greater macrophage heterogeneity in the ulcerative colitis and Crohn's colitis biopsies than in normal mucosa, and the degree of this replacement correlated with the histological severity of the disease. Expand
DNA patterns of Helicobacter pylori isolated from gastric antrum, body, and duodenum.
The genetic heterogeneity of H. pylori is unexplained but it could be of considerable value for epidemiological studies. Expand
Alimentary Pharmacology & Therapeutics
Professor W L Peterson, Co-Editor During the past 2 years, Professor Peterson has received honoraria from AstraZeneca Pharmaceuticals. In addition, he was a principal in EBMed, a for-profitExpand
Comparison of three RNA amplification methods as sources of DNA for sequencing.
The results indicated that cloned DNA products generated by RT-nPCRs possessed least errors and that for NASBA, RT of reaction products before cloning and sequencing was preferable to using RT-PCR. Expand
Early mucosal changes in Crohn's disease.
Examination of areas of apparently normal and non-inflamed bowel in Crohn's disease has allowed the identification of mucosal changes which occur before macroscopic and microscopic ulceration, including small mucosal capillaries which were not apparent otherwise. Expand