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Role of Genotype in the Cycle of Violence in Maltreated Children
TLDR
A functional polymorphism in the gene encoding the neurotransmitter-metabolizing enzyme monoamine oxidase A was found to moderate the effect of maltreatment, and it was found that Maltreated children with a genotype conferring high levels of MAOA expression were less likely to develop antisocial problems. Expand
Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene
TLDR
Evidence of a gene-by-environment interaction is provided, in which an individual's response to environmental insults is moderated by his or her genetic makeup. Expand
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene.
TLDR
Evidence of a gene-by-environment interaction is provided, in which an individual's response to environmental insults is moderated by his or her genetic makeup. Expand
A gradient of childhood self-control predicts health, wealth, and public safety
TLDR
Following a cohort of 1,000 children from birth to the age of 32 y, it is shown that childhood self-control predicts physical health, substance dependence, personal finances, and criminal offending outcomes, following a gradient of self- control. Expand
Female and male antisocial trajectories: From childhood origins to adult outcomes
TLDR
Findings support similarities across gender with respect to developmental trajectories of antisocial behavior and their associated childhood origins and adult consequences. Expand
Prior juvenile diagnoses in adults with mental disorder: developmental follow-back of a prospective-longitudinal cohort.
TLDR
Most adult disorders should be reframed as extensions of juvenile disorders, in particular, juvenile conduct disorder is a priority prevention target for reducing psychiatric disorder in the adult population. Expand
The p Factor
TLDR
The structure of psychopathology is examined, taking into account dimensionality, persistence, co-occurrence, and sequential comorbidity of mental disorders across 20 years, from adolescence to midlife, to explain why it is challenging to find causes, consequences, biomarkers, and treatments with specificity to individual mental disorders. Expand
Cannabis use in adolescence and risk for adult psychosis: longitudinal prospective study
TLDR
This is the first prospective longitudinal study of adolescent cannabis use as a risk factor for adult schizophreniform disorder, taking into account childhood psychotic symptoms, and the Dunedin multidisciplinary health and development study has a 96% follow up rate at age 26. Expand
Persistent cannabis users show neuropsychological decline from childhood to midlife
TLDR
Persistent cannabis use was associated with neuropsychological decline broadly across domains of functioning, even after controlling for years of education and cessation of cannabis use, suggestive of a neurotoxic effect of cannabis on the adolescent brain. Expand
Children's self-reported psychotic symptoms and adult schizophreniform disorder: a 15-year longitudinal study.
TLDR
These findings provide the first evidence for continuity of psychotic symptoms from childhood to adulthood, and the link between child and adult psychotic symptoms was not the result of general childhood psychopathology. Expand
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