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Photodynamic therapy (PDT) and photodiagnosis (PD) using endogenous photosensitization induced by 5-aminolevulinic acid (ALA): mechanisms and clinical results.
TLDR
The current state of knowledge of the mechanisms of endogenous topical and systemic photosensitization using ALA, the results of published clinical trials, and possible methods of increasing the efficacy of endogenous photosensItization for ALA PDT are reviewed in this paper.
Phototoxic damage to sebaceous glands and hair follicles of mice after systemic administration of 5-aminolevulinic acid correlates with localized protoporphyrin IX fluorescence.
TLDR
The skin of albino mice given 5-aminolevulinic acid by intraperitoneal injection rapidly developed the characteristic red fluorescence of protoporphyrin IX and appeared to recover completely except for a persistent reduction in the number of hair follicles.
The nature of the chromophore responsible for naturally occurring fluorescence in mouse skin.
On the role of protoporphyrin IX photoproducts in photodynamic therapy.
A COMPARISON OF FLUORESCENCE METHODS USED IN THE PHARMACOKINETIC STUDIES OF Zn(II)PHTHALOCYANINE IN MICE
TLDR
The in vivo measurements at two different anatomical sites showed pharmacokinetic behavior that reflects an overall integrated fluorescence originating from several tissue sites, consistent with previous findings on the pharmacokinetics of ZnPc.
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