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Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy
We describe that galectin-1 (gal-1) is a receptor for the angiogenesis inhibitor anginex, and that the protein is crucial for tumor angiogenesis. gal-1 is overexpressed in endothelial cells ofExpand
Ubiad1 Is an Antioxidant Enzyme that Regulates eNOS Activity by CoQ10 Synthesis
TLDR
Surprisingly, inhibition of eNOS prevents Ubiad1-dependent cardiovascular oxidative damage, suggesting a crucial role for this enzyme and nonmitochondrial CoQ10 in NO signaling. Expand
Zebrafish integrin-linked kinase is required in skeletal muscles for strengthening the integrin-ECM adhesion complex.
TLDR
Ilk is an essential intracellular component downstream of laminin and itgalpha7, providing strengthening of skeletal muscle fibre adhesion with the ECM and therefore qualified as a novel candidate gene for congenital muscular dystrophy. Expand
Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells.
TLDR
This is the first report on mutations in the laminin, integrin, and ILK system in humanCardiomyopathy, which has consequences for endothelial cells as well as for cardiomyocytes, thus providing a new genetic basis for dilated carduomyopathy in humans. Expand
Laminin-&agr;4 and Integrin-Linked Kinase Mutations Cause Human Cardiomyopathy Via Simultaneous Defects in Cardiomyocytes and Endothelial Cells
TLDR
This is the first report on mutations in the laminin, integrin, and ILK system in humanCardiomyopathy, which has consequences for endothelial cells as well as for cardiomyocytes, thus providing a new genetic basis for dilated carduomyopathy in humans. Expand
Nesprin-3 augments peripheral nuclear localization of intermediate filaments in zebrafish
TLDR
Zebrafish nesprin-3 is dispensable for normal development in zebrafish, but important for mediating the association of the intermediate filament system with the nucleus in vivo. Expand
Apelin: A putative novel predictive biomarker for bevacizumab response in colorectal cancer
TLDR
A DNA microarray-based transcriptional profiling screen with primary endothelial cells (ECs) isolated from normal and tumour colon tissues revealed that VEGF-induced genes were overexpressed in tumour ECs; these genes could relate to bvz response and serve as potential predictive biomarkers. Expand
Carbonic Anhydrase 5 Regulates Acid-Base Homeostasis in Zebrafish
TLDR
It is shown that CA5 regulates acid-base balance during embryonic development, since lowering the pH can compensate for the loss of CA5 activity. Expand
Kindlin-1 mutant zebrafish as an in vivo model system to study adhesion mechanisms in the epidermis.
TLDR
The rof/kindlin-1 mutant zebrafish provides a unique model system to study epidermal adhesion mechanisms in vivo and reveals that residues K610, W612, and I647 in the F3 domain are essential for Kindlin- 1 function in vivo, and thatKindlin-2 can functionally compensate for the loss of Kindrin-1. Expand
Abstract 1103: Integrin-linked Kinase and Laminin alpha 4 Mutations Cause Human Cardiomyopathy
Background - Dilated Cardiomyopathy (DCM) is a syndrome characterized by ventricular dilation, contractile dysfunction and symptoms of congestive heart failure. Extracellular matrix proteins such a...
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