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Palmitoylation Regulates Epidermal Homeostasis and Hair Follicle Differentiation
This study is the first to demonstrate a key role for palmitoylation in regulating developmental signals in mammalian tissue homeostasis and shows that the Src-family kinase, Fyn, involved in keratinocyte differentiation, is a direct palmitoyslation target of Zdhhc21 and is mislocalized in mutant follicles. Expand
Mutations in gasdermin 3 cause aberrant differentiation of the hair follicle and sebaceous gland.
Investigation of the role of the gasdermin gene family revealed that gasdermins are expressed specifically in cells at advanced stages of differentiation in the upper epidermis, the differentiating inner root sheath and hair shaft and in the most mature sebocytes of the sebaceous gland and preputial, meibomium, ceruminous gland, and anal glands. Expand
Characterization of early assembly intermediates of recombinant human keratins.
It is shown here that keratins, like other cytoplasmic IF proteins, go through a stage of assembling into full-width soluble complexes, i.e., "unit-length filaments" (ULFs), and suggests that the "heads" are involved in the formation and longitudinal association of the ULFs. Expand
K15 Expression Implies Lateral Differentiation within Stratified Epithelial Basal Cells
Different differences in their expression patterns have been observed that imply different regulation and function for these two genes, and K15 appears to be preferentially expressed in stable or slowly turning over basal cells. Expand
Pathways to inflammation: acne pathophysiology.
The following review aims to link factors, including familial link, the impact of their diet and the association with their hormones, with the end result - inflammation. Expand
Phenotypes, genotypes and their contribution to understanding keratin function.
Evidence is emerging that the great diversity of keratins might be required to enable cells to adapt their structure in response to different signalling pathways. Expand
Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects
BACKGROUND Atopic dermatitis (AD) is a major inflammatory condition of the skin caused by inherited skin barrier deficiency, with mutations in the filaggrin gene predisposing to development of AD.Expand
Human keratin 8 mutations that disturb filament assembly observed in inflammatory bowel disease patients
Impaired keratin assembly resulting from the K8 mutations found in some inflammatory bowel disease patients would be predicted to affect the maintenance and re-establishment of mechanical resilience in vivo, as required during keratin cytoskeleton remodeling in cell division and differentiation, which may lead to epithelial fragility in the gut. Expand
Alopecia in a novel mouse model RCO3 is caused by mK6irs1 deficiency.
Results indicate that the expression of functional mK6irs1 is indispensable for intermediate filament formation in the inner root sheath and highlights the importance of the keratinization of the innerroot sheath in the normal formation of the hair shaft. Expand
Gene targeting at the mouse cytokeratin 10 locus: severe skin fragility and changes of cytokeratin expression in the epidermis
The existence of the murine equivalent of human cytokeratin 16 is demonstrated, for the first time, in mice with different phenotypes in the homozygotes and heterozygotes; both of which exhibit similarities to specific clinical characteristics of bullous congenital ichthyosiform erythroderma. Expand