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Regulation of the CDK-related protein kinase PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A cells.
PCTAIRE-1 is a CDK-related protein kinase found in terminally differentiated cells in brain and testis, and in many immortalised and transformed cell lines. Bacterially expressed PCTAIRE isExpand
Cyclin A in cell cycle control and cancer
Abstract. Cyclin A is particularly interesting among the cyclin family because it can activate two different cyclin-dependent kinases (CDKs) and functions in both S phase and mitosis. An embryonicExpand
The multiple checkpoint functions of CHK1 and CHK2 in maintenance of genome stability.
  • Yue Chen, R. Poon
  • Biology, Medicine
  • Frontiers in bioscience : a journal and virtual…
  • 1 May 2008
Cell cycle checkpoints are pivotal mechanisms safeguarding genome stability. Cells that harbor defects in checkpoints are predisposed to genome instability and neoplastic transformation. TwoExpand
Dephosphorylation of Cdk2 Thr160 by the Cyclin-Dependent Kinase-Interacting Phosphatase KAP in the Absence of Cyclin
The activation of cyclin-dependent kinases (CDKs) requires the phosphorylation of a conserved threonine (Thr160 in Cdk2) by CDK-activating kinase (CAK). Human KAP (also called Cdi1), a CDK-associatedExpand
Cyclin-dependent Kinases Are Inactivated by a Combination of p21 and Thr-14/Tyr-15 Phosphorylation after UV-induced DNA Damage*
The cyclin-dependent kinase (CDK) inhibitor p21 is induced by the tumor suppressor gene product p53 and is thought to be important for the arrest of the cell cycle following DNA damage. Here we haveExpand
A roller coaster ride with the mitotic cyclins.
  • T. Fung, R. Poon
  • Biology, Medicine
  • Seminars in cell & developmental biology
  • 1 June 2005
Cyclins are discovered as proteins that accumulate progressively through interphase and disappear abruptly at mitosis during each cell cycle. In mammalian cells, cyclin A accumulates from late G1Expand
Cyclin-Dependent Kinases and S Phase Control in Mammalian Cells
Mammalian DNA replication is an elegantly choreographed process in which multiple components are assembled at the origins to form the prereplication complex. Formation and activation of theExpand
Inactivation of p27Kip1 by the viral E1A oncoprotein in TGFβ-treated cells
THE adenovirus oncoprotein E1A and the simian virus SV40 large T antigen can both reverse the strong growth-inhibitory effect of transforming growth factor(TGF)-β on mink lung epithelial cells1,2:Expand
TRIP13 Regulates Both the Activation and Inactivation of the Spindle-Assembly Checkpoint.
Biochemical studies have indicated that p31(comet) and TRIP13 are critical for inactivating MAD2. To address unequivocally whether p31(comet) and TRIP13 are required for mitotic exit at the cellularExpand
MDM2 and MDMX can interact differently with ARF and members of the p53 family
Members of the p53 family of transcription factors have essential roles in tumor suppression and in development. MDM2 is an essential regulator of p53 that can inhibit the transcriptional activity ofExpand
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