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Nucleic acid-functionalized Pt nanoparticles: Catalytic labels for the amplified electrochemical detection of biomolecules.
- R. Polsky, Ron Gill, Lubov Kaganovsky, I. Willner
- Chemistry, BiologyAnalytical chemistry
- 18 February 2006
The association of aptamer-functionalized Pt- NPs to a throm bin aptamer/thrombin complex associated with an electrode allowed the amplified, electrocatalytic detection of thrombin with a sensitivity limit corresponding to 1 x 10(-9) M.
Metal nanoparticle-based electrochemical stripping potentiometric detection of DNA hybridization.
The new electrochemical stripping metallogenomagnetic protocol couples the inherent signal amplification of stripping metal analysis with discrimination against nonhybridized DNA, the use of microliter sample volumes, and disposable transducers and, hence, offers great promise for decentralized genetic testing.
Magnetically-induced solid-state electrochemical detection of DNA hybridization.
- Joseph Wang, Danke Xu, R. Polsky
- Materials ScienceJournal of the American Chemical Society
- 28 March 2002
The new method couples high sensitivity of silver-amplified assays with effective discrimination against excess of closely related nucleotide sequences (including single-base imperfections) and could be applied to other bioaffinity assays.
Microfabricated electrophoresis chips for simultaneous bioassays of glucose, uric acid, ascorbic acid, and acetaminophen.
Coupling of enzymatic assays with electrophoretic separations on a microchip platform holds great promise for rapid testing of metabolites (such as glucose or lactate), as well as for the introduction of high-speed clinical microanalyzers based on multichannel chips.
Genomagnetic electrochemical assays of DNA hybridization.
Electrochemical stripping detection of DNA hybridization based on cadmium sulfide nanoparticle tags
Pt nanoparticles functionalized with nucleic acid act as catalytic labels for the chemiluminescent detection of DNA and proteins.
“Electroactive Beads” for Ultrasensitive DNA Detection
This work reports on a new strategy for amplifying electrical DNA sensing based on the use of microsphere tags loaded internally with a redox marker, capable of carrying a huge number of the ferrocenecarboxaldehyde marker molecules and offering a remarkable amplification of single hybridization events.
Extraction and biomolecular analysis of dermal interstitial fluid collected with hollow microneedles
An approach for extracting dermal interstitial fluid (ISF) using an array of hollow microneedles in a cylindrical substrate that minimizes skin compression and tissue damage is presented, and a previously unexplored biofluid for exosome isolation is reported.
Diazonium-functionalized horseradish peroxidase immobilized via addressable electrodeposition: direct electron transfer and electrochemical detection.
- R. Polsky, J. Harper, S. Dirk, D. C. Arango, D. Wheeler, S. Brozik
- ChemistryLangmuir : the ACS journal of surfaces and…
- 16 January 2007
The direct electrically addressable deposition of diazonium-modified enzymes is examined for electrochemical sensor applications and studies of direct electron transfer of enzymes can benefit from protein electrodes prepared by this method.