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Principal components analysis corrects for stratification in genome-wide association studies
TLDR
This work describes a method that enables explicit detection and correction of population stratification on a genome-wide scale and uses principal components analysis to explicitly model ancestry differences between cases and controls. Expand
STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus.
TLDR
A haplotype of STAT4 is associated with increased risk for both rheumatoid arthritis and systemic lupus erythematosus, suggesting a shared pathway for these illnesses. Expand
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations
TLDR
New candidate genes for serum urate concentration highlight the importance of metabolic control of urate production and excretion, which may have implications for the treatment and prevention of gout. Expand
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
TLDR
Seven new rheumatoid arthritis risk alleles were identified at genome-wide significance (P < 5 × 10−8) in an analysis of all 41,282 samples, and an additional 11 SNPs replicated at P < 0.05, suggesting that most represent genuine rhearatoid arthritisrisk alleles. Expand
Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4.
TLDR
Support is provided for PTPN22, CTLA4, and PADI4 as RA susceptibility genes and novel associations with clinically relevant subsets of RA are demonstrated. Expand
Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus
TLDR
A genome-wide association scan and replication study and evidence of two independent signals near TNFAIP3 associated with SLE, including one previously associated with rheumatoid arthritis are found. Expand
JAK and STAT signaling molecules in immunoregulation and immune-mediated disease.
TLDR
Not only have genome-wide association studies demonstrated that this pathway is highly relevant to human autoimmunity, but targeting JAKs is now a reality in immune-mediated disease. Expand
Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis
TLDR
Imputation of functional variation from large reference panels can help fine map association signals in the MHC, and three amino acid positions in HLA-DRβ1, which are all located in peptide-binding grooves, almost completely explain the M HC association to rheumatoid arthritis risk. Expand
Genetics of rheumatoid arthritis contributes to biology and drug discovery
TLDR
A genome-wide association study meta-analysis in a total of >100,000 subjects of European and Asian ancestries provides empirical evidence that the genetics of RA can provide important information for drug discovery, and sheds light on fundamental genes, pathways and cell types that contribute to RA pathogenesis. Expand
Defining the Role of the MHC in Autoimmunity: A Review and Pooled Analysis
TLDR
A number of interesting commonalities and differences across diseases that implicate both general and disease-specific pathogenetic mechanisms in autoimmunity are found. Expand
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