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High‐resolution NMR studies of the zinc‐binding site of the Alzheimer's amyloid β‐peptide
Metal binding to the amyloid β‐peptide is suggested to be involved in the pathogenesis of Alzheimer's disease. We used high‐resolution NMR to study zinc binding to amyloid β‐peptide 1–40 atExpand
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Protonless NMR experiments for sequence-specific assignment of backbone nuclei in unfolded proteins.
Natively unfolded proteins are increasingly recognized to play important physiological roles. These proteins do not crystallize, so NMR is the only technique able to provide structural and dynamicExpand
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The Atx1-Ccc2 complex is a metal-mediated protein-protein interaction
Cellular systems allow transition-metal ions to reach or leave the cell or intracellular locations through metal transfer between proteins. By coupling mutagenesis and advanced NMR experiments, weExpand
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Fast resonance assignment and fold determination of human superoxide dismutase by high-resolution proton-detected solid-state MAS NMR spectroscopy.
Re-protonation is key: A combination of a high magnetic field (1 GHz) and ultra-fast magic-angle spinning (60 kHz) allows easy detection of NMR spectra revealing details of secondary and tertiaryExpand
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Complete assignment of heteronuclear protein resonances by protonless NMR spectroscopy.
Keywords: carbon NMR spectroscopy ; NMR spectroscopy ; protein structures ; proteins ; spin-state selection Reference EPFL-ARTICLE-204420doi:10.1002/anie.200461794View record in Web of Science RecordExpand
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pE-DB: a database of structural ensembles of intrinsically disordered and of unfolded proteins
TLDR
The goal of pE-DB (http://pedb.vib.be) is to serve as an openly accessible database for the deposition of structural ensembles of intrinsically disordered proteins (IDPs) and of denatured proteins based on nuclear magnetic resonance spectroscopy, small-angle X-ray scattering and other data measured in solution. Expand
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Conformational space of flexible biological macromolecules from average data.
The concept of maximum occurrence (MO), i.e., the maximum percent of time that flexible proteins can spend in any given conformation, is introduced, and a rigorous method is developed to extensivelyExpand
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Structure and backbone dynamics of a microcrystalline metalloprotein by solid-state NMR
We introduce a new approach to improve structural and dynamical determination of large metalloproteins using solid-state nuclear magnetic resonance (NMR) with 1H detection under ultrafast magic angleExpand
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13C direct detection experiments on the paramagnetic oxidized monomeric copper, zinc superoxide dismutase.
In this report, the use of 13C direct detection has been pursued in 2D experiments (13C-13C COSY, 13C-13C COCAMQ, 13C-13C NOESY) to detect broad lines in nuclear magnetic resonance spectra ofExpand
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