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Studies of the Diabetogenic Action of Streptozotocin.∗
TLDR
While the B-cytotoxic effects of streptozotocin resemble those of alloxan, their specificity is very much greater, as demonstrated by the wide margin between diabetogenic dose and general toxicity.
Sequence of the human insulin gene
TLDR
A comparison of the human with the rat insulin genes indicates potential regulatory regions in the DNA segment preceding the gene and suggests that the ancestral form of the insulin gene had two intervening sequences.
Rat insulin genes: construction of plasmids containing the coding sequences.
Recombinant bacterial plasmids have been constructed that contain complementary DNA prepared from rat islets of Langerhans messenger RNA. Three plasmids contain cloned sequences representing the
THE ENDOCRINE CELLS IN THE EPITHELIUM OF THE GASTROINTESTINAL MUCOSA OF THE RAT
TLDR
The authors of this study examine the question of whether the so-called enterochromaffin or argentaffin cells of the gastrointestinal tract should be considered as a single cell type, and their appearance corresponds to that of pancreatic D cells.
The expression cassette determines the functional activity of ribozymes in mammalian cells by controlling their intracellular localization.
TLDR
It is demonstrated that the ribozyme expression cassette determines its intracellular localization and, hence, its corresponding functional activity.
Cell-type specific activity of two glucocorticoid responsive units of rat tyrosine aminotransferase gene is associated with multiple binding sites for C/EBP and a novel liver-specific nuclear factor
TLDR
DNAase I footprinting and gel mobility shift analyses reveal a complex array of contiguous and overlapping sites for cell type-specific DNA binding proteins in the remote glucocorticoid responsive units.
Hepatocyte nuclear factor 3 determines the amplitude of the glucocorticoid response of the rat tyrosine aminotransferase gene.
TLDR
The better knowledge of the sequence determinant recognized by HNF3 has allowed us to analyze its function in the glucocorticoid response of the rat tyrosine aminotransferase gene, and results indicate that H NF3 accounts for most of the liver-specific activity of this GRU.
Cloning and sequence analysis of cDNAs encoding two distinct somatostatin precursors found in the endocrine pancreas of anglerfish
TLDR
Homologies in the amino acid sequences of the two peptides outside the somatostatin moiety suggest other regions of the molecules have biological functions.
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