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Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy.
TLDR
Each BP has a unique profile that may help to explain potential important clinical differences among the BPs, in terms of speed of onset of fracture reduction, antifracture efficacy at different skeletal sites, and the degree and duration of suppression of bone turnover. Expand
Exosome Delivered Anticancer Drugs Across the Blood-Brain Barrier for Brain Cancer Therapy in Danio Rerio
TLDR
Brain endothelial cell derived exosomes could be potentially used as a carrier for brain delivery of anticancer drug for the treatment of brain cancer. Expand
Bone Material Properties in Trabecular Bone From Human Iliac Crest Biopsies After 3‐ and 5‐Year Treatment With Risedronate
TLDR
In this double‐blinded study, 3‐ and 5‐year treatment with risedronate arrested the tissue aging encountered in untreated osteoporosis and in osteop orosis treated with other antiresorptives. Expand
MicroRNA‐10b regulates tumorigenesis in neurofibromatosis type 1
TLDR
The results suggest that miR‐10b may play an important role in NF1 tumorigenesis through targeting neurofibromin and RAS signaling. Expand
The composition of tracheal mucus and the nervous control of its secretion in the cat
TLDR
It is shown that sympathetic nerve stimulation and sympathomimeticamines increase tracheal mucus output and parasympathetic nerve (vagal) stimulation increases mucus protein output and the strength of this effect is about the same as that of sympathetic nerve stimulating. Expand
Modulation of sclerostin expression by mechanical loading and bone morphogenetic proteins in osteogenic cells.
TLDR
The results indicate that BMP treatment and in vitro mechanical loading demonstrate opposite effects upon sclerostin expression, suggesting its pivotal role in modulating bone formation. Expand
Alterations in canine vertebral bone turnover, microdamage accumulation, and biomechanical properties following 1-year treatment with clinical treatment doses of risedronate or alendronate.
TLDR
It is document that 1 year of bisphosphonate treatment at clinical doses allows significant accumulation of microdamage in the vertebra but this is offset by increases in bone volume and mineralization such that there is no significant impairment of mechanical properties. Expand
Inhibition of Protein Prenylation by Bisphosphonates Causes Sustained Activation of Rac, Cdc42, and Rho GTPases
TLDR
N‐BPs, which inhibit bone resorption by preventing prenylation of small GTPases, unexpectedly cause the accumulation of GTP‐bound, unprenylated Rho family GTPase in macrophages and osteoclasts, causing inappropriate activation of downstream signaling pathways. Expand
Changes in non-enzymatic glycation and its association with altered mechanical properties following 1-year treatment with risedronate or alendronate
TLDR
One year of high-dose bisphosphonate therapy in dogs allowed the increased accumulation of advanced glycation end-products (AGEs) and reduced postyield work-to-fracture of the cortical bone matrix, suggesting that increased AGEs may contribute to a more brittle bone matrix. Expand
Risedronate Preserves Trabecular Architecture and Increases Bone Strength in Vertebra of Ovariectomized Minipigs as Measured by Three‐Dimensional Microcomputed Tomography
TLDR
The study showed that risedronate preserved trabecular architecture in the vertebra of OVX minipigs, and that bone strength is tightly coupled to bone mass and architecture. Expand
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