Share This Author
Two MscS Homologs Provide Mechanosensitive Channel Activities in the Arabidopsis Root
Cardiac Mechano-Gated Ion Channels and Arrhythmias.
This review focuses on acute mechanical effects on cardiac electrophysiology, explores molecular candidates underlying observed responses, and discusses their pharmaceutical regulation.
Piezo1‐dependent stretch‐activated channels are inhibited by Polycystin‐2 in renal tubular epithelial cells
Findings indicate that renal SACs depend on Piezo1, but are critically conditioned by PC2, and PC2 coimmunoprecipitates withPiezo1 and deletion of its N‐terminal domain prevents both this interaction and inhibition of SAC activity.
Piezo1 in Smooth Muscle Cells Is Involved in Hypertension-Dependent Arterial Remodeling.
Multiple modalities converge on a common gate to control K2P channel function
- Sviatoslav N. Bagriantsev, R. Peyronnet, K. Clark, E. Honoré, D. Minor
- BiologyThe EMBO journal
- 15 July 2011
A unique gating mechanism shared by K2P family members is defined and it is suggested that their diverse sensory properties are achieved by coupling different molecular sensors to a conserved core gating apparatus.
- A. Klesen, D. Jakob, Ramona Emig, P. Kohl, U. Ravens, R. Peyronnet
- MedicineHerzschrittmachertherapie + Elektrophysiologie
- 1 February 2018
Fibrotic areas in cardiac muscle—be it in ventricular or atrial tissue—are considered as obstacles for conduction of the excitatory wave and can therefore facilitate re-entry, which may contribute to…
Piezo 1-dependent stretch-activated channels are inhibited by Polycystin-2 in renal tubular epithelial cells
Molecular candidates for cardiac stretch-activated ion channels
What is known about the molecular substrate of the main candidates for cardiac SAC is summarised, before identifying potential further developments in this area of translational research.
The NSL complex maintains nuclear architecture stability via lamin A/C acetylation
Collectively, the NSL-complex-dependent lamin A/C acetylation provides a mechanism that maintains nuclear architecture and genome integrity and is termed “heterochromatin enrichment in nuclear abnormalities” (HENA).
A Human TREK-1/HEK Cell Line: A Highly Efficient Screening Tool for Drug Development in Neurological Diseases
The development of the first available cell line that constituvely expresses the TREK-1 channel is described, which has conserved all its modulation properties and is protected against ischemia by using the oxygen-glucose deprivation model.