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Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms
Stargazer, an ataxic and epileptic mutant mouse, lacks functional AMPA receptors on cerebellar granule cells, and expression of a mutant stargazin lacking the PDZ-binding domain in hippocampal pyramidal cells disrupts synaptic AMPA receptor receptors, indicating that st argazin-like mechanisms for targeting AM PA receptors may be widespread in the central nervous system.
Coupling of mGluR/Homer and PSD-95 Complexes by the Shank Family of Postsynaptic Density Proteins
Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation.
Tetanic synaptic stimulation induced a rapid delivery of tagged receptors into dendritic spines as well as clusters in dendrites and may contribute to the enhanced AMPA receptor-mediated transmission observed during long-term potentiation and activity-dependent synaptic maturation.
Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins
A general role for TARPs is indicated in controlling synaptic AMPA receptors throughout the central nervous system.
A Developmental Change in NMDA Receptor-Associated Proteins at Hippocampal Synapses
- N. Sans, R. Petralia, Ya‐Xian Wang, J. Blahoš, J. Hell, R. Wenthold
- BiologyThe Journal of Neuroscience
- 1 February 2000
These studies suggest that there is a preference for complexes of NR2A/PSD-93/95 and NR2B/SAP-102 and that individual receptor-associated proteins may have specific functions that are critical to synapse development.
Homer Regulates the Association of Group 1 Metabotropic Glutamate Receptors with Multivalent Complexes of Homer-Related, Synaptic Proteins
Phosphorylation of the AMPA Receptor GluR1 Subunit Is Required for Synaptic Plasticity and Retention of Spatial Memory
Arc/Arg3.1 Interacts with the Endocytic Machinery to Regulate AMPA Receptor Trafficking
Light and electron immunocytochemical localization of AMPA‐selective glutamate receptors in the rat brain
Staining was most prominent in forebrain structures such as the olfactory bulb and tubercle, septal nuclei, amygdaloid complex, hippocampus, induseum griseum, habenula, and interpeduncular nucleus, and in the cerebellum, with limited evidence of stained presynaptic terminals, excepting Bergmann glia.
Activation of the TRPC1 cation channel by metabotropic glutamate receptor mGluR1
It is reported that the mGluR1-evoked slow EPSC is mediated by the TRPC1 cation channel, which is expressed in perisynaptic regions of the cerebellar parallel fibre–Purkinje cell synapse and is physically associated with mGLUR1.